Local anesthetic
This page covers all Local anesthetic drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Voltage-gated sodium channels, Sodium channels.
Targets
Voltage-gated sodium channels · Sodium channels
Marketed (104)
- Topical liquid lidocaine · OHSU Knight Cancer Institute · Oncology (supportive care)
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. - Bupivacaine- physiological solution · SEBASTIAN ROCHE · Anesthesia
Bupivacaine blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and propagation of action potentials. - intrarectal lidocaine gel · Bagcilar Training and Research Hospital · Gastroenterology
Lidocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - liposomal bupivacaine local infiltration · Second Affiliated Hospital, School of Medicine, Zhejiang University · Anesthesia/Pain Management
Liposomal bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses when infiltrated into tissue. - Liposomal lidocaine · The Hospital for Sick Children · Anesthesia/Pain Management
Liposomal lidocaine is a local anesthetic encapsulated in liposomes that blocks sodium channels in nerve cell membranes to prevent pain signal transmission. - Digital nerve block with bupivacaine · Tehran University of Medical Sciences · Anesthesia
Bupivacaine blocks sodium channels in nerve fibers, preventing the generation and propagation of action potentials to produce local anesthesia in the digital nerves. - Lidocaine per-embolization · University Health Network, Toronto · Interventional Radiology / Pain Management
Lidocaine is a local anesthetic administered before embolization procedures to reduce pain and discomfort during the interventional radiological intervention. - Topical Lidocaine · Aultman Health Foundation · Pain management / Anesthesia
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. - Intraperitoneal lidocaine irrigation group · Chung-Ang University Hosptial, Chung-Ang University College of Medicine · Pain management / Surgery
Intraperitoneal lidocaine irrigation delivers a local anesthetic directly into the peritoneal cavity to reduce postoperative pain and inflammation. - Lidocaine patch 1.8% · Scilex Pharmaceuticals, Inc. · Pain management
Lidocaine blocks sodium channels in nerve fibers, interrupting pain signal transmission at the site of application. - Bupivacaine 20cc · Hospital for Special Surgery, New York · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses. - Bupivacaine Digital Block · University of California, San Francisco · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce regional anesthesia. - Bupivacaine Hcl 0.5% Inj · Hospital for Special Surgery Florida · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Bupivacaine Injection [Marcaine] · South Egypt Cancer Institute · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Bupivacaine 0.167% · Bozyaka Training and Research Hospital · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Bupivacaine FNB · Pacira Pharmaceuticals, Inc · Pain Management / Regional Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and conduction of nerve impulses. - Regular bupivacaine · Vanderbilt University Medical Center · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses. - Same Bupivacaine Concentration · University of Chile · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Intra-articular Lidocaine · University of Central Florida · Pain management / Orthopedics
Lidocaine blocks sodium channels in nerve fibers to provide local anesthesia and pain relief when injected directly into the joint space. - Marcaine 0.25 % Injectable Solution · Connecticut Children's Medical Center · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - L:Lidocaine · B.P. Koirala Institute of Health Sciences · Anesthesia
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Continuous Infusion of ropivacaine 0.2% · University of California, San Diego · Anesthesia/Pain Management
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials and thereby producing local anesthesia. - Topical Benzocaine 20% · Nourhan M.Aly · Anesthesia / Pain Management
Benzocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Topical Benzocaine · University of Maryland, Baltimore · Anesthesia/Pain Management
Benzocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Topical Lidocaine 4% Cream · Children's Hospital of Philadelphia · Anesthesia/Pain Management
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. - Ice T · University Hospitals Cleveland Medical Center · Anesthesiology
Ice T is an anesthetic and analgesic agent. - Ropivacaine concentration low · Oslo University Hospital · Anesthesia
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. - Bupivacaine low dose · Fundacion para la Investigacion Biomedica del Hospital Universitario Principe de Asturias · Anesthesia/Pain Management
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. - Bupivacaine Hcl 0.75% Inj · Rothman Institute Orthopaedics · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Anesthetics, Local · University of Alberta · Anesthesiology
Local anesthetics block sodium channels in nerve cell membranes, preventing the generation and propagation of action potentials to produce localized numbness and pain relief. - Lidocaine 2% Injectable Solution · Erasme University Hospital · Anesthesia
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia. - Lidocaine 2% Jelly · Hermann Eye Center · Anesthesia/Ophthalmology
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia. - Bupivacaine Hydrochloride And Epinephrine · Pfizer
Bupivacaine blocks nerve impulses by increasing the threshold for electrical excitation, slowing nerve impulse propagation, and reducing the rate of rise of the action potential. - Lidocaine + Prilocaine · Galeno Desenvolvimento de Pesquisas Clínicas · Anesthesia/Pain Management
Lidocaine and prilocaine are local anesthetics that block sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Lidocaine solution ("A") · Hospital Universitari de Bellvitge · Anesthesia / Pain Management
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. - Lidocaine gel 2% · Atlantic Health System · Anesthesia/Pain Management
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. - Marcaine Injectable Product · University of California, Davis · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Bupivacaine indwelling catheter · Denver Health and Hospital Authority · Anesthesia/Pain Management
Bupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce local anesthesia. - Bupivacaine in epidural catheter · Odense University Hospital · Anesthesia
Bupivacaine blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce local anesthesia. - Nerve block with Lidocain · Tehran University of Medical Sciences · Anesthesia
Lidocaine blocks sodium channels in nerve fibers, preventing the generation and propagation of action potentials to produce local anesthesia.
Phase 3 pipeline (45)
- US-guided tenotomy with lidocaine · Jose Ignacio Martin · Pain management
Lidocaine is a local anesthetic that blocks nerve signals, preventing pain. - Liposomal Bupivacaine with Bupivacaine · Jamaica Hospital Medical Center · Anesthesia / Pain Management
Liposomal bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, with the liposomal formulation providing prolonged drug release and extended anesthesia duration. - Ropivacaine 0.25% Injectable Solution · Rothman Institute Orthopaedics · Anesthesiology
Ropivacaine is a local anesthetic that works by blocking nerve impulses, preventing pain. - Arm II (ESMESOL) · Gangnam Severance Hospital · Anesthesiology
Esmesol is a local anesthetic that works by blocking sodium channels in nerve cells, preventing the initiation and transmission of nerve impulses. - LRA Loco-regional anesthesia · University Hospital, Angers · Anesthesiology
LRA delivers local anesthetic agents directly to a specific anatomical region to block nerve conduction and provide regional anesthesia for surgical or procedural pain control. - Oxybuprocaine/fluorescein SDU · Medical University of Vienna · Ophthalmology
Oxybuprocaine/fluorescein SDU is a local anesthetic and a fluorescent dye used to visualize the corneal endothelium. - Benzokain Sprey · TC Erciyes University · Pain management / Anesthesia
Benzocaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission. - Caudal block with levobupivacaine · University of Novi Sad · Anesthesia
Levobupivacaine administered via caudal block provides regional anesthesia by blocking sodium channels in nerve fibers, preventing pain signal transmission to the central nervous system. - Nebulised Bupivacaine intraperitoneally · Imperial College London · Pain management / Surgery
Nebulised bupivacaine delivered intraperitoneally provides local anesthetic effect to reduce postoperative pain and inflammation within the peritoneal cavity. - Bupivacaine HCl collagen-matrix implant · Innocoll · Pain management / Surgery
Bupivacaine HCl is released from a collagen matrix implant to provide local anesthesia at the surgical site. - Pharyngal® Oromucosal Spray · Bosnalijek D.D · Pain management
Pharyngal Oromucosal Spray is a local anesthetic used to relieve pain in the throat. - Port-sites infiltration:Bupivacaine0.25% · Hospital General Universitario Elche · Anesthesiology
Bupivacaine blocks sodium channels in nerve fibers, preventing depolarization and relieving pain. - lidocaine in Vaseline ointment · University Medical Center Nijmegen · Cardiovascular
Lidocaine works by blocking sodium channels in nerve cells, preventing the initiation and transmission of nerve impulses. - Ropivacaine irrigation · Hospital General Universitario Elche · Anesthesiology
Ropivacaine is a local anesthetic that works by blocking sodium channels in nerve fibers, preventing the initiation and transmission of nerve impulses. - Injected Bupivacaine intraperitoneally · Imperial College London · Pain management / Anesthesia
Bupivacaine injected intraperitoneally blocks sodium channels in nerve fibers within the peritoneal cavity, providing local anesthesia and analgesia to abdominal tissues. - SABER-Bupivacaine · Durect · Pain management
SABER-Bupivacaine is a sustained-release formulation of bupivacaine, a local anesthetic that blocks nerve impulses. - Ropivacaine nebulization · San Gerardo Hospital · Anesthesiology
Ropivacaine is a local anesthetic that works by blocking sodium channels in nerve fibers, preventing the initiation and transmission of nerve impulses. - Benzocaine Otic Solution · Lachlan Pharma Holdings · Otology / Pain Management
Benzocaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission in the ear. - Ropivacaine with epinephrine injection · Seoul National University Hospital · Anesthesiology
Ropivacaine with epinephrine injection works by blocking nerve signals to provide local anesthesia and vasoconstriction. - Topical 2,5% lidocaine + 2,5% prilocaine gel · Pontificia Universidad Catolica de Chile · Pain management
Lidocaine and prilocaine work by blocking the action of sodium channels in nerve cells, preventing the transmission of pain signals. - bupivacaine S75:R25 plus 8% glucose · Cristália Produtos Químicos Farmacêuticos Ltda. · Anesthesiology
Bupivacaine is a local anesthetic that blocks sodium channels to prevent nerve impulses. - Bupivicaine alone · The Cleveland Clinic · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses. - TCA IR 40 · Pacira Pharmaceuticals, Inc · Pain management
TCA IR 40 is a local anesthetic that works by blocking nerve signals. - Oxybuprocaine MDU · Medical University of Vienna · Ophthalmology
Oxybuprocaine MDU is a local anesthetic that works by blocking sodium channels in nerve fibers, preventing the initiation and transmission of nerve impulses. - Lidocaine Injectable Solution · Groupe Hospitalier Diaconesses Croix Saint-Simon · Anesthesia
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. - lidocaine treatment · Centre Hospitalier Universitaire, Amiens · Cardiovascular
Lidocaine blocks sodium channels in nerve cells, preventing the initiation and transmission of nerve impulses. - spinal administration of lidocaine · St. Antonius Hospital · Anesthesiology
Lidocaine blocks sodium channels in nerve cells, preventing the initiation and transmission of nerve impulses. - chirocaine (Levobupivacaine) · Centre Hospitalier Universitaire de Saint Etienne · Anesthesiology
Chirocaine (Levobupivacaine) is a local anesthetic that blocks nerve impulses by inhibiting sodium channels. - bupivacaine S50:R50 plus 8% glucose · Cristália Produtos Químicos Farmacêuticos Ltda. · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. - Mepivacaine 2% with epinephrine 1:100,000 · Qassim Health Cluster · Anesthesiology
Mepivacaine is a local anesthetic that blocks sodium channels to prevent nerve impulses, while epinephrine constricts blood vessels to prolong the anesthetic effect. - L+E maxillary anesthesia · University of Belgrade · Anesthesia / Dentistry
L+E maxillary anesthesia is a local anesthetic formulation designed to provide regional anesthesia in the maxillary region of the oral cavity. - peribulbar block 1 lidocaine/bupivacaine · Centro Medico Docente la Trinidad · Anesthesiology
Lidocaine and bupivacaine work by blocking sodium channels in nerve fibers, preventing the transmission of pain signals. - Naropin, 0.5% Injectable Solution · Cali Pharmaceuticals LLC · Pain management
Naropin is a local anesthetic that works by blocking sodium channels in nerve fibers, preventing the initiation and transmission of nerve impulses. - L+E mandibular anesthesia · University of Belgrade · Anesthesia / Dentistry
L+E mandibular anesthesia is a local anesthetic formulation designed to provide regional anesthesia of the mandibular nerve for dental and oral surgical procedures. - Femoral Nerve Block Bupivacaine · The New England Baptist Hospital · Anesthesia / Pain Management
Bupivacaine blocks sodium channels in nerve fibers, preventing the generation and propagation of action potentials to produce local anesthesia in the femoral nerve distribution. - Local infiltration of lidocaine · Kasr El Aini Hospital · Anesthesia / Pain Management
Lidocaine blocks sodium channels in nerve cell membranes, preventing depolarization and transmission of pain signals. - Local infiltration analgesia · Medical University of Graz · Pain Management / Anesthesia
Local infiltration analgesia delivers anesthetic agents directly into surgical tissue planes to block pain signals at the site of injury. - opioid free anesthesia · Peking University People's Hospital · Anesthesiology
opioid-free anesthesia works by using a combination of local anesthetics and adjuvants to provide pain relief without the use of opioids. - Locoregional anesthesia · Hospices Civils de Lyon · Anesthesia / Pain Management
Locoregional anesthesia blocks nerve conduction locally to produce reversible loss of sensation in a specific anatomical region without affecting consciousness. - Local Anesthesia · University of Maryland, Baltimore · Anesthesia
Local anesthetics block sodium channels in nerve cell membranes to prevent the initiation and conduction of nerve impulses, thereby producing localized numbness and pain relief.
Phase 2 pipeline (11)
- Bupivacaine HCl Treatment 2c · Durect · Anesthesiology
Bupivacaine HCl is a local anesthetic that blocks nerve impulses, preventing pain. - Chloroprocaine HCl 1% · Sintetica SA · Anesthesiology
Chloroprocaine HCl 1% is a local anesthetic that works by blocking nerve impulses in the body. - Antipyrine-benzocaine otic solution · Global United Pharmaceutical Corporation · Ophthalmology
Antipyrine-benzocaine otic solution works by providing local anesthetic and analgesic effects to the ear. - Bupivacaine 0.25-0.5% · Rabin Medical Center · Anesthesiology
Bupivacaine is a local anesthetic that blocks nerve impulses, preventing pain. - Bupivacaine hydrochloride 1% · Express Specialty Pharmacy · Oncology
Local anesthetic by blocking sodium channels - Bupivacaine HCl Treatment 1c · Durect · Pain management
Bupivacaine HCl is a local anesthetic that works by blocking sodium channels in nerve fibers to prevent the initiation and transmission of nerve impulses. - Chloroprocaine 2% Injectable Solution · Sintetica SA · Oncology
Local anesthetic by blocking sodium channels - Anesthetic blockades with bupivacaine · César Fernández-de-las-Peñas · Pain management
Bupivacaine works by blocking sodium channels in nerve fibers, preventing the initiation and transmission of nerve impulses. - DLX105 Hydrogel · Delenex Therapeutics AG · Pain management
DLX105 Hydrogel is a hydrogel formulation of a local anesthetic. - Intravenous Lignocain · Shaheed Mohtarma Benazir Bhutto Institue of Trauma · Oncology
Blocks sodium channels - Autologous blood transfusion with ropivacaine · Northern Orthopaedic Division, Denmark · Anesthesiology
Autologous blood transfusion with ropivacaine involves reinfusing a patient's own blood that has been collected and treated with ropivacaine to reduce pain.