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Local infiltration analgesia
Local infiltration analgesia delivers anesthetic agents directly into surgical tissue planes to block pain signals at the site of injury.
Local infiltration analgesia delivers anesthetic agents directly into surgical tissue planes to block pain signals at the site of injury. Used for Postoperative pain management in surgical patients, Acute pain relief following surgical procedures.
At a glance
| Generic name | Local infiltration analgesia |
|---|---|
| Also known as | dexmedetomidine, Ropivacaine |
| Sponsor | Medical University of Graz |
| Drug class | Local anesthetic |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Anesthesia |
| Phase | Phase 3 |
Mechanism of action
This technique involves injecting local anesthetic solutions (such as liposomal bupivacaine or other local anesthetics) directly into the surgical wound or tissue planes during or after surgery. The anesthetic diffuses through the tissue to block nerve conduction and provide prolonged postoperative pain relief at the surgical site, reducing the need for systemic opioids.
Approved indications
- Postoperative pain management in surgical patients
- Acute pain relief following surgical procedures
Common side effects
- Local tissue irritation or inflammation
- Systemic anesthetic toxicity (if absorbed)
- Allergic reaction
Key clinical trials
- Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients" (NA)
- A Clinical Trial Evaluating the Efficacy, Safety, and Pharmacokinetic Profile of TRD303 for Postoperative Analgesia After Abdominal Surgery in China. (PHASE3)
- Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration for Postoperative Analgesia in Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial (NA)
- Erector Spinae Block Vs Ketamine-based Multimodal Analgesia Protocol in Lumber Decompressive Surgery (NA)
- Herniorrhaphy for Postoperative Pain (PHASE3)
- Postoperative Analgesia and Ventilation After Cardiac Surgery
- ERAS (Enhanced Recovery After Surgery) and Multimodal Analgesia in Laparoscopic Cholecystectomy
- Local Infiltration Analgesia Versus Quadruple Nerve Blocks in Total Knee Arthroplasty. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |