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Lidocaine 2% Jelly
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia.
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia. Used for Topical anesthesia of the eye and ocular surface, Anesthesia for ophthalmic procedures and examinations.
At a glance
| Generic name | Lidocaine 2% Jelly |
|---|---|
| Also known as | Lidocaine Jelly, Lidocaine gel |
| Sponsor | Hermann Eye Center |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Ophthalmology |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in nerve fibers. This prevents depolarization and the generation of action potentials, thereby blocking nerve conduction. The jelly formulation allows topical application for surface anesthesia of mucous membranes and tissues.
Approved indications
- Topical anesthesia of the eye and ocular surface
- Anesthesia for ophthalmic procedures and examinations
Common side effects
- Transient eye irritation
- Temporary blurred vision
- Allergic contact dermatitis (rare)
Key clinical trials
- Closed Versus Open Lateral Internal Sphincterotomy for Chronic Anal Fissure (NA)
- This Clinical Trial Aims to Compare the Effectiveness of Two Intra-pulpal Cryotherapy Techniques-Endo-ice and Ice Sticks-in Decreasing Intra-operative Pain and Enhancing the Success of Local Anesthesia During Pulpectomy of Mandibular Molars With Symptomatic Irreversible Pulpitis. (NA)
- Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal Injections (PHASE4)
- The Use of Lidocaine Gel Versus Subconjunctival Xylocaine Injection in Pterygium Excision (PHASE4)
- Cryotherapy as a Topical Anesthetic in Healthy Children (PHASE4)
- Effect of Injectable Hyaluronic Acid (HYADENT BG (HA)) on Bone Healing in Extraction Sockets (NA)
- Post-Menopause Skin Rejuvenation Study (PHASE4)
- Different Transcutaneous Electrical Nerve Stimulation Modes in Pudendal Neuralgia Post-prostatectomy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |