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Bupivacaine in epidural catheter
Bupivacaine blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce local anesthesia.
Bupivacaine blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce local anesthesia. Used for Epidural anesthesia and analgesia for surgical procedures, Epidural analgesia for labor and delivery, Postoperative pain management via epidural catheter.
At a glance
| Generic name | Bupivacaine in epidural catheter |
|---|---|
| Sponsor | Odense University Hospital |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting local anesthetic that penetrates nerve sheaths and reversibly binds to sodium channels on the inner surface of nerve cell membranes. By blocking sodium influx, it prevents depolarization and conduction of nerve impulses in the area of administration. When delivered via epidural catheter, it provides regional anesthesia and analgesia to the lower body and lower extremities.
Approved indications
- Epidural anesthesia and analgesia for surgical procedures
- Epidural analgesia for labor and delivery
- Postoperative pain management via epidural catheter
Common side effects
- Hypotension
- Bradycardia
- Headache
- Nausea
- Systemic toxicity (CNS and cardiac effects at high doses)
- Urinary retention
Key clinical trials
- Retrolaminar Block Versus Subcostal Transversus Abdominis Plane Block in Liver Resection Surgery (NA)
- Thoracic Epidural Analgesia or Four-Quadrant Transversus Abdominus Plane Block in Reducing Pain in Patients Undergoing Liver Surgery (PHASE3)
- Epidural vs. Dural Puncture Epidural in Labor Analgesia (NA)
- Thoracic Epidural Analgesia With Bilateral Erector Spinae Plane Block in Radical Cystectomy Surgery (NA)
- Spinal Anesthesia For Enhanced Recovery After Liver Surgery (NA)
- Patient Preference and Long-term Outcomes in Persistent Spinal Pain Syndrome: A Prospective Study Comparing Spinal Cord Stimulation to Intrathecal Drug Delivery. (PHASE4)
- Dural Puncture Epidural vs Standard Epidural Analgesia in Labor (NA)
- Sensory Block Onset: Epidural vs Dural Puncture Epidural in Cesarean Section (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine in epidural catheter CI brief — competitive landscape report
- Bupivacaine in epidural catheter updates RSS · CI watch RSS
- Odense University Hospital portfolio CI