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intrarectal lidocaine gel
Lidocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Lidocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Rectal pain and discomfort associated with hemorrhoids, Anal fissures, Anorectal procedures and post-procedure pain relief.
At a glance
| Generic name | intrarectal lidocaine gel |
|---|---|
| Also known as | No name |
| Sponsor | Bagcilar Training and Research Hospital |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
When applied rectally as a gel, lidocaine penetrates the rectal mucosa and reversibly inhibits sodium influx into nerve fibers, thereby stabilizing the neuronal membrane and reducing the excitability of sensory and motor nerves. This produces local anesthesia and pain relief in the rectal and perirectal tissues, commonly used to alleviate discomfort associated with hemorrhoids, anal fissures, and other anorectal conditions.
Approved indications
- Rectal pain and discomfort associated with hemorrhoids
- Anal fissures
- Anorectal procedures and post-procedure pain relief
Common side effects
- Local irritation or burning sensation
- Allergic contact dermatitis
- Systemic toxicity (rare with topical rectal use)
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
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