{"id":"intrarectal-lidocaine-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning sensation"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Systemic toxicity (rare with topical rectal use)"}]},"_chembl":{"chemblId":"CHEMBL79","moleculeType":"Small molecule","molecularWeight":"234.34"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"When applied rectally as a gel, lidocaine penetrates the rectal mucosa and reversibly inhibits sodium influx into nerve fibers, thereby stabilizing the neuronal membrane and reducing the excitability of sensory and motor nerves. This produces local anesthesia and pain relief in the rectal and perirectal tissues, commonly used to alleviate discomfort associated with hemorrhoids, anal fissures, and other anorectal conditions.","oneSentence":"Lidocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:49:39.873Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rectal pain and discomfort associated with hemorrhoids"},{"name":"Anal fissures"},{"name":"Anorectal procedures and post-procedure pain relief"}]},"trialDetails":[{"nctId":"NCT02025361","phase":"PHASE4","title":"Impact of Local Anesthesia Type on Cancer Detection Rate in Transrectal Ultrasound Guided Prostate Biopsy","status":"COMPLETED","sponsor":"Bagcilar Training and Research Hospital","startDate":"2009-02","conditions":"Adenocarcinoma of Prostate","enrollment":422}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["No name"],"phase":"marketed","status":"active","brandName":"intrarectal lidocaine gel","genericName":"intrarectal lidocaine gel","companyName":"Bagcilar Training and Research Hospital","companyId":"bagcilar-training-and-research-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lidocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Rectal pain and discomfort associated with hemorrhoids, Anal fissures, Anorectal procedures and post-procedure pain relief.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}