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Ropivacaine concentration low
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Local and regional anesthesia for surgical procedures, Peripheral nerve blocks, Epidural anesthesia.
At a glance
| Generic name | Ropivacaine concentration low |
|---|---|
| Sponsor | Oslo University Hospital |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and nerve impulse transmission. This results in local anesthesia in the area of administration. The 'low concentration' formulation refers to a dilute preparation used for specific clinical applications requiring reduced systemic toxicity risk.
Approved indications
- Local and regional anesthesia for surgical procedures
- Peripheral nerve blocks
- Epidural anesthesia
Common side effects
- Injection site reactions
- Transient neurological symptoms
- Hypotension
- Bradycardia
- Systemic toxicity (at high doses)
Key clinical trials
- Efficacy of Methylene Blue Plus Ropivacaine for Post-Hemorrhoidectomy Pain. (PHASE4)
- To Observe the Clinical Effect of Femoral Nerve Block With Low Concentration of Ropivacaine Based on DPN Grading
- Low Concentration Local Anesthesia Fascia Iliaca Block for Total Hip Arthroplasty (NA)
- Effects of Ropivacaine Concentrations on Prolonged Labor Analgesia (NA)
- Ropivacaine Concentration and Rebound Pain (PHASE4)
- Exploring the Minimum Effective Concentration and Volume of Ropivacaine for Sacral Plexus Anesthesia (PHASE4)
- The Effect of Brachial Plexus Block on Diaphragm Movement (NA)
- Multicenter Study of Chloroprocaine Versus Ropivacaine for Epidural Labor Analgesia (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ropivacaine concentration low CI brief — competitive landscape report
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- Oslo University Hospital portfolio CI