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Bupivacaine- physiological solution
Bupivacaine blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and propagation of action potentials.
Bupivacaine is a local anesthetic used for various surgical and diagnostic procedures. It is administered as a physiological solution by SEBASTIAN ROCHE. Despite its effectiveness, it does not have an FDA label, which may limit its use in certain markets. The drug is known for its long-lasting anesthetic properties but comes with a range of potential side effects that need to be carefully managed. Its use is primarily in regional anesthesia, including epidural and spinal blocks.
At a glance
| Generic name | Bupivacaine- physiological solution |
|---|---|
| Sponsor | SEBASTIAN ROCHE |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
By inhibiting sodium influx through ion channels, bupivacaine prevents depolarization of nerve fibers, thereby blocking the initiation and conduction of nerve impulses. This local anesthetic effect is reversible and allows for temporary loss of sensation in a localized area. The physiological solution formulation provides appropriate osmolarity and pH for safe administration.
Approved indications
- Local and regional anesthesia for surgical procedures
- Infiltration anesthesia
- Nerve blocks
- Epidural and spinal anesthesia
Common side effects
- Systemic toxicity (CNS effects: tremor, seizures)
- Cardiovascular effects (hypotension, arrhythmias)
- Local reactions (pain, erythema at injection site)
- Allergic reactions
Key clinical trials
- Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty (NA)
- Comparison of Erector Spinae Plane Block and Caudal Block in Pediatric Patients Aged 1 to 8 Years Undergoing Lower Abdominal Surgery (NA)
- Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery (PHASE4)
- Analgesic Efficacy of Bilateral Erector Spinae Plane Block in Pediatric Tethered Cord Syndrome Surgery (NA)
- Rectus Sheath Block for Analgesia After Gynecological Laparotomy (PHASE4)
- Ultrasound-Guided Versus Laparoscopy-Guided Transversus Abdominis Plane Block for Postoperative Analgesia (NA)
- Postoperative Analgesic Efficacy Between Adductor Canal Block + IPACK Block and Adductor Canal Block + Genicular Nerve Block in Total Knee Arthroplasty (NA)
- Quality Of Recovery After Pericapsular Nerve Group (PENG) Block For Hip Hemiarthroplasty Under Spinal Anesthesia (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine- physiological solution CI brief — competitive landscape report
- Bupivacaine- physiological solution updates RSS · CI watch RSS
- SEBASTIAN ROCHE portfolio CI