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Lidocaine + Prilocaine

Galeno Desenvolvimento de Pesquisas Clínicas · FDA-approved active Small molecule

Lidocaine + Prilocaine is a Local anesthetic Small molecule drug developed by Galeno Desenvolvimento de Pesquisas Clínicas. It is currently FDA-approved for Topical anesthesia of intact skin prior to minor surgical procedures, Topical anesthesia for venipuncture and intravenous cannulation, Topical anesthesia for dermatological procedures. Also known as: Nanorap®.

Lidocaine and prilocaine are local anesthetics that block sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.

Lidocaine and prilocaine are local anesthetics that block sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Topical anesthesia of intact skin prior to minor surgical procedures, Anesthesia for venipuncture and intravenous cannulation, Relief of pain associated with minor skin procedures.

At a glance

Generic nameLidocaine + Prilocaine
Also known asNanorap®
SponsorGaleno Desenvolvimento de Pesquisas Clínicas
Drug classLocal anesthetic
TargetVoltage-gated sodium channels
ModalitySmall molecule
Therapeutic areaAnesthesia/Pain Management
PhaseFDA-approved

Mechanism of action

Both agents are amide-type local anesthetics that work by inhibiting sodium influx through voltage-gated sodium channels in neuronal membranes, thereby stabilizing the membrane and preventing depolarization. This combination is commonly formulated as EMLA cream (Eutectic Mixture of Local Anesthetics), where the two drugs form a eutectic mixture with enhanced penetration through intact skin. The synergistic effect allows for effective topical anesthesia with reduced systemic toxicity compared to either agent alone.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Lidocaine + Prilocaine

What is Lidocaine + Prilocaine?

Lidocaine + Prilocaine is a Local anesthetic drug developed by Galeno Desenvolvimento de Pesquisas Clínicas, indicated for Topical anesthesia of intact skin prior to minor surgical procedures, Topical anesthesia for venipuncture and intravenous cannulation, Topical anesthesia for dermatological procedures.

How does Lidocaine + Prilocaine work?

Lidocaine and prilocaine are local anesthetics that block sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.

What is Lidocaine + Prilocaine used for?

Lidocaine + Prilocaine is indicated for Topical anesthesia of intact skin prior to minor surgical procedures, Topical anesthesia for venipuncture and intravenous cannulation, Topical anesthesia for dermatological procedures.

Who makes Lidocaine + Prilocaine?

Lidocaine + Prilocaine is developed and marketed by Galeno Desenvolvimento de Pesquisas Clínicas (see full Galeno Desenvolvimento de Pesquisas Clínicas pipeline at /company/galeno-desenvolvimento-de-pesquisas-cl-nicas).

Is Lidocaine + Prilocaine also known as anything else?

Lidocaine + Prilocaine is also known as Nanorap®.

What drug class is Lidocaine + Prilocaine in?

Lidocaine + Prilocaine belongs to the Local anesthetic class. See all Local anesthetic drugs at /class/local-anesthetic.

What development phase is Lidocaine + Prilocaine in?

Lidocaine + Prilocaine is FDA-approved (marketed).

What are the side effects of Lidocaine + Prilocaine?

Common side effects of Lidocaine + Prilocaine include Skin blanching or erythema at application site, Temporary skin pallor, Methemoglobinemia (rare, especially in infants), Local irritation or allergic contact dermatitis.

What does Lidocaine + Prilocaine target?

Lidocaine + Prilocaine targets Voltage-gated sodium channels and is a Local anesthetic.

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