{"id":"lidocaine-prilocaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin blanching or erythema at application site"},{"rate":null,"effect":"Temporary skin pallor"},{"rate":null,"effect":"Methemoglobinemia (rare, especially in infants)"},{"rate":null,"effect":"Local irritation or allergic contact dermatitis"}]},"_chembl":null,"_dailymed":{"setId":"82111bef-460f-4948-a19c-1d2063427ee4","title":"LIDOCAINE AND PRILOCAINE CREAM [PREFERRED PHARMACEUTICALS INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Both agents are amide-type local anesthetics that work by inhibiting sodium influx through voltage-gated sodium channels in neuronal membranes, thereby stabilizing the membrane and preventing depolarization. This combination is commonly formulated as EMLA cream (Eutectic Mixture of Local Anesthetics), where the two drugs form a eutectic mixture with enhanced penetration through intact skin. The synergistic effect allows for effective topical anesthesia with reduced systemic toxicity compared to either agent alone.","oneSentence":"Lidocaine and prilocaine are local anesthetics that block sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T06:11:43.235Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical anesthesia of intact skin prior to minor surgical procedures"},{"name":"Topical anesthesia for venipuncture and intravenous cannulation"},{"name":"Topical anesthesia for dermatological procedures"}]},"trialDetails":[{"nctId":"NCT07471854","phase":"NA","title":"Efficacy and Safety of Combined Nanofat Injection With Either Platelet Rich Fibrin or Microneedling Versus Nanofat Injection Alone in the Treatment of Facial Atrophic Post Acne Scars","status":"NOT_YET_RECRUITING","sponsor":"Assiut 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