Voltage-gated sodium channels — Drug Target
All drugs that target Voltage-gated sodium channels — marketed and clinical-stage. Includes 27 drug classes acting on this target.
Drug classes
Local anesthetic (liposomal formulation) · Local anesthetic (amide) · Local anesthetic (amide class) · Local anesthetic · Local anesthetic; antiarrhythmic agent · Local anesthetic combination · Local anesthetic with vasoconstrictor · Long-acting local anesthetic · Local anesthetic (ester) · Local anesthetic (amino amide) · Local anesthetic / Antiarrhythmic agent · Aromatic antiepileptic drug (hydantoin)
Marketed (200)
- Exparel/bupivacaine mixture · Wake Forest University Health Sciences · Local anesthetic (liposomal formulation) · Pain Management / Anesthesia
Exparel is a liposomal formulation of bupivacaine that provides prolonged local anesthesia by slowly releasing the anesthetic agent from lipid vesicles at the injection site. - Ropivacaine Hydrocloride · Women's Hospital HUS · Local anesthetic (amide) · Anesthesia/Pain Management
Ropivacaine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - bupivacaine 0.25 % injection · Ain Shams University · Local anesthetic (amide class) · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses. - Bupivacaine 0.167% · Bozyaka Training and Research Hospital · Local anesthetic · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Intravenous Lidocaine · Khon Kaen University · Local anesthetic; antiarrhythmic agent · Anesthesia; Cardiology; Pain management
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Bupivacaine (Hyperbaric 0.5%) · Guy's and St Thomas' NHS Foundation Trust · Local anesthetic · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - extraarticular injection with ropivacaine · Hvidovre University Hospital · Local anesthetic · Anesthesia/Pain Management
Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce local anesthesia. - Lidoderm 5 % Topical Patch · Oregon Health and Science University · Local anesthetic · Pain management / Dermatology
Lidocaine blocks sodium channels in nerve fibers, interrupting pain signal transmission when applied topically to the skin. - PIB 0.2% ropivacaine · University Health Network, Toronto · Local anesthetic (amide class) · Anesthesia
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. - Dyclonine hydrochloride mucilage · Peking Union Medical College Hospital · Local anesthetic · Pain management / Otolaryngology
Dyclonine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission. - Bupivacaine %0.25 (isobaric) · Bursa City Hospital · Local anesthetic (amide class) · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. - guided injection of mepivacaine · Complejo Hospitalario Universitario de Granada · Local anesthetic (amide) · Anesthesia / Pain Management
Mepivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission. - Bupivacaine 0.125% · Shanghai Pulmonary Hospital, Shanghai, China · Local anesthetic · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Bupivacaine 0.5% · Kasr El Aini Hospital · Local anesthetic (amide class) · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses. - Bupivacaine 0.5% (hyperbaric) · Nazmy Edward Seif · Local anesthetic (amide class) · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. - Bupivacaine plus Lidocaine · University of Alabama at Birmingham · Local anesthetic combination · Anesthesia / Pain Management
Bupivacaine and lidocaine are local anesthetics that block sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - ropivacaine (Naropin) · University of Zurich · Local anesthetic (amide) · Anesthesia
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. - Ropivicaine with Epinephrine · Health Sciences North Research Institute · Local anesthetic with vasoconstrictor · Anesthesia/Pain Management
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission, while epinephrine is a vasoconstrictor that prolongs the anesthetic's duration and reduces systemic absorption. - Same Bupivacaine Concentration · University of Chile · Local anesthetic · Anesthesia
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Instillation - EXPAREL · Pacira Pharmaceuticals, Inc · Long-acting local anesthetic · Pain Management / Anesthesia
EXPAREL is a long-acting local anesthetic that blocks sodium channels in nerve fibers to provide prolonged post-operative pain relief. - Isobaric 2-chloroprocaine · Centre Hospitalier Universitaire Saint Pierre · Local anesthetic (ester) · Anesthesia
Isobaric 2-chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission. - Levobupivacaine epidural bolus · University of Genova · Local anesthetic (amino amide) · Anesthesia
Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. - Levobupivacaine PCA group · Osijek University Hospital · Local anesthetic (amide) · Anesthesia / Pain Management
Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. - IP Lignocaine bolus and infusion · University of Auckland, New Zealand · Local anesthetic / Antiarrhythmic agent · Anesthesia / Cardiology
Lignocaine (lidocaine) is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Chloroprocaine Injection [Clorotekal] · Oregon Health and Science University · Local anesthetic (ester) · Anesthesia
Chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Lidocaine jelly application · Keimyung University Dongsan Medical Center · Local anesthetic · Pain management / Anesthesia
Lidocaine jelly is a topical local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission. - L:Lidocaine · B.P. Koirala Institute of Health Sciences · Local anesthetic · Anesthesia
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - MEPIVACAÍNE · Complexo Hospitalario Universitario de A Coruña · Local anesthetic (amide) · Anesthesia
Mepivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Continuous Infusion of ropivacaine 0.2% · University of California, San Diego · Local anesthetic · Anesthesia/Pain Management
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials and thereby producing local anesthesia. - Topical Benzocaine · University of Maryland, Baltimore · Local anesthetic · Anesthesia/Pain Management
Benzocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Xylocaine Injectable Solution · University of Puerto Rico · Local anesthetic · Anesthesia
Xylocaine (lidocaine) is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. - Trigger point injection with bupivacaine · George Washington University · Local anesthetic · Pain Management
Bupivacaine blocks sodium channels in nerve fibers, interrupting pain signal transmission when injected directly into trigger points. - Lidocaine 1%/Epi 1:200000 · Wahba bakhet · Local anesthetic with vasoconstrictor · Anesthesia/Pain Management
Lidocaine blocks sodium channels in nerve cell membranes to produce local anesthesia, while epinephrine causes vasoconstriction to prolong the anesthetic effect and reduce systemic absorption. - Proparacaine Ophthalmic · American Genomics, LLC · Local anesthetic (ester) · Ophthalmology
Proparacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission in the eye. - Exparel Injectable Solution · The Cooper Health System · Local anesthetic (liposomal formulation) · Pain Management / Anesthesia
Liposomal bupivacaine is an encapsulated local anesthetic that blocks nerve impulses by inhibiting sodium channel activity, providing prolonged pain relief after surgical procedures. - Exparel Injectable Product · Pacira Pharmaceuticals, Inc · Local anesthetic (liposomal formulation) · Pain Management / Anesthesia
Exparel is a liposomal formulation of bupivacaine that provides prolonged local anesthesia by slowly releasing the anesthetic agent over an extended period. - alkalinized lidocaine · Massachusetts General Hospital · Local anesthetic · Anesthesia/Pain Management
Alkalinized lidocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, with alkalinization enhancing its tissue penetration and onset speed. - Epidural analgesia Ropivacaine · Universitair Ziekenhuis Brussel · Local anesthetic (amide class) · Anesthesia/Pain Management
Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce regional anesthesia. - Extended Phenytoin Sodium · Bristol-Myers Squibb · Aromatic antiepileptic drug (hydantoin) · Neurology
Extended-release phenytoin sodium blocks voltage-gated sodium channels in the brain to reduce neuronal excitability and prevent seizure propagation. - Ropivacaine concentration low · Oslo University Hospital · Local anesthetic · Anesthesia
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.