Local anesthetic combination

This page covers all Local anesthetic combination drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Voltage-gated sodium channels; NMDA receptor, Voltage-gated sodium channels, Voltage-gated sodium channels (bupivacaine); alpha-1 adrenergic receptors (epinephrine); glucocorticoid receptor (dexamethasone).

Targets

Voltage-gated sodium channels; NMDA receptor · Voltage-gated sodium channels · Voltage-gated sodium channels (bupivacaine); alpha-1 adrenergic receptors (epinephrine); glucocorticoid receptor (dexamethasone) · Voltage-gated sodium channels (bupivacaine); acetylcholinesterase (neostigmine)

Marketed (8)

• Lidocaine/Magnesium · University of Wisconsin, Madison · Pain management / Anesthesia
  Lidocaine blocks sodium channels to provide local anesthesia, while magnesium acts as a co-factor to enhance anesthetic efficacy and reduce pain signaling.
• Bupivacaine plus Lidocaine · University of Alabama at Birmingham · Anesthesia / Pain Management
  Bupivacaine and lidocaine are local anesthetics that block sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
• Bupivacaine/epinephrine/dexamethasone · Cedars-Sinai Medical Center · Anesthesia/Pain Management
  This is a combination injection containing bupivacaine (local anesthetic), epinephrine (vasoconstrictor), and dexamethasone (corticosteroid) that blocks nerve conduction, maintains local drug concentration, and reduces inflammation at the injection site.
• Lidocaine/tetracaine patch · East Carolina University · Pain management / Anesthesia
  Lidocaine and tetracaine are local anesthetics that block sodium channels in nerve fibers, preventing pain signal transmission at the site of application.
• Ropivacine and Chloroprocaine mixture · University of New Mexico · Anesthesia / Pain Management
  This mixture of two local anesthetics blocks sodium channels in nerve fibers to prevent pain signal transmission.
• Lidocaine 7% + Tetracaine 7% cream · Galderma R&D · Dermatology / Pain Management
  Lidocaine and tetracaine are local anesthetics that block sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce topical anesthesia.
• Lidocaine-chlorprocaine combination · Hadassah Medical Organization · Anesthesia
  This combination of two local anesthetics blocks sodium channels in nerve fibers to produce rapid onset and prolonged duration of local anesthesia.
• bupivacaine/ neostigmine. · Ain Shams University · Anesthesia / Pain Management
  Bupivacaine provides local anesthesia by blocking sodium channels in nerve fibers, while neostigmine enhances and prolongs this effect by inhibiting acetylcholinesterase.

Phase 3 pipeline (3)

• L+C mandibular anesthesia · University of Belgrade · Anesthesia / Dentistry
  L+C mandibular anesthesia is a local anesthetic formulation designed to provide regional anesthesia of the mandibular nerve for dental and oral surgical procedures.
• Lidocaine tetracaine cream · Cutia Therapeutics（Wuxi）Co.,Ltd · Dermatology
  Lidocaine and tetracaine are local anesthetics that block sodium channels in nerve cell membranes to inhibit pain signal transmission.
• L+C maxillary anesthesia · University of Belgrade · Anesthesia / Dentistry
  L+C maxillary anesthesia is a local anesthetic formulation designed to provide regional anesthesia in the maxillary region of the oral cavity.