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Lidocaine/Magnesium
Lidocaine blocks sodium channels to provide local anesthesia, while magnesium acts as a co-factor to enhance anesthetic efficacy and reduce pain signaling.
Lidocaine blocks sodium channels to provide local anesthesia, while magnesium acts as a co-factor to enhance anesthetic efficacy and reduce pain signaling. Used for Topical anesthesia and pain relief (specific indication not fully characterized in public literature).
At a glance
| Generic name | Lidocaine/Magnesium |
|---|---|
| Sponsor | University of Wisconsin, Madison |
| Drug class | Local anesthetic combination |
| Target | Voltage-gated sodium channels; NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Pain management / Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that inhibits voltage-gated sodium channels in nerve fibers, preventing action potential propagation and blocking pain transmission. Magnesium potentiates this effect by modulating NMDA receptors and reducing neuronal excitability, enhancing the overall analgesic and anesthetic properties of the combination. This synergistic approach is used topically or locally to provide rapid pain relief.
Approved indications
- Topical anesthesia and pain relief (specific indication not fully characterized in public literature)
Common side effects
- Local irritation or erythema
- Allergic reaction to lidocaine
- Systemic toxicity (if absorbed in high amounts)
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
- Comparison of Changes in Intra-myocardial Amino Acids During Use of Calafiore and Modified Del Nido Cardioplegia
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
- Magnesium Sulfate as an Adjuvant to Lidocaine in MPDS Trigger Point Injections Assessed by VAS and sEMG. (NA)
- Intravenous Lidocaine, Ketamine, and Magnesium in Thoracic Surgery
- Lidocaine vs Magnesium Sulfate for Hemodynamic Stability During Emergence in Infertility-Related Laparoscopic Surgery" (NA)
- COMPARISON OF OPIOID-FREE AND OPIOID-BASED ANESTHESIA TECHNIQUES ON qNOX INDEX IN ABDOMINAL SURGERY UNDER GENERAL ANESTHESIA (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lidocaine/Magnesium CI brief — competitive landscape report
- Lidocaine/Magnesium updates RSS · CI watch RSS
- University of Wisconsin, Madison portfolio CI