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Lidocaine-chlorprocaine combination
This combination of two local anesthetics blocks sodium channels in nerve fibers to produce rapid onset and prolonged duration of local anesthesia.
This combination of two local anesthetics blocks sodium channels in nerve fibers to produce rapid onset and prolonged duration of local anesthesia. Used for Local and regional anesthesia for infiltration and nerve blocks.
At a glance
| Generic name | Lidocaine-chlorprocaine combination |
|---|---|
| Sponsor | Hadassah Medical Organization |
| Drug class | Local anesthetic combination |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a fast-acting local anesthetic that rapidly blocks sodium influx in nerve membranes, while chlorprocaine is an ester local anesthetic with intermediate onset. The combination leverages lidocaine's quick onset with chlorprocaine's duration to provide both rapid anesthesia initiation and extended anesthetic coverage for surgical and procedural applications.
Approved indications
- Local and regional anesthesia for surgical and procedural applications
Common side effects
- Injection site reactions
- Transient paresthesia
- Allergic reactions (rare with amide-ester combination)
- Systemic toxicity (at high doses)
Key clinical trials
- Randomized Controlled Trial of Combined Lidocaine - Chlorprocaine in Labor Epidural Analgesia. (PHASE4)
- Comparison of Chloroprocaine vs Lidocaine for Epidural Anesthesia in Cesarean Delivery (EARLY_PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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