Lidocaine-chlorprocaine combination — Competitive Intelligence Brief

Lidocaine-chlorprocaine combination (Lidocaine-chlorprocaine combination) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Local anesthetic combination. Area: Anesthesia.

marketed Local anesthetic combination Voltage-gated sodium channels Anesthesia Small molecule

Target snapshot

Lidocaine-chlorprocaine combination (Lidocaine-chlorprocaine combination) — Hadassah Medical Organization. This combination of two local anesthetics blocks sodium channels in nerve fibers to produce rapid onset and prolonged duration of local anesthesia.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Lidocaine-chlorprocaine combination TARGET	Lidocaine-chlorprocaine combination	Hadassah Medical Organization	marketed	Local anesthetic combination	Voltage-gated sodium channels
Standard dose topiramate	Standard dose topiramate	Mario Negri Institute for Pharmacological Research	marketed	Anticonvulsant / Antiepileptic agent	Voltage-gated sodium channels, GABA-A receptors, carbonic anhydrase
Bupivacaine %0.25 (isobaric)	Bupivacaine %0.25 (isobaric)	Bursa City Hospital	marketed	Local anesthetic (amide class)	Voltage-gated sodium channels
Regular bupivacaine	Regular bupivacaine	Vanderbilt University Medical Center	marketed	Local anesthetic	Voltage-gated sodium channels
Bupivacain (Postoperative)	Bupivacain (Postoperative)	Başakşehir Çam & Sakura City Hospital	marketed	Local anesthetic (amide class)	Voltage-gated sodium channels
LD: Lidocaine and dexamethasone	LD: Lidocaine and dexamethasone	B.P. Koirala Institute of Health Sciences	marketed	Local anesthetic with corticosteroid combination	Voltage-gated sodium channels (lidocaine); glucocorticoid receptor (dexamethasone)
Bupivacaine 0.25% with Epinephrine	Bupivacaine 0.25% with Epinephrine	Holy Cross Hospital, Florida	marketed	Local anesthetic with vasopressor	Voltage-gated sodium channels

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Local anesthetic combination class)

1. University of Belgrade · 2 drugs in this class
2. Cedars-Sinai Medical Center · 1 drug in this class
3. Cutia Therapeutics（Wuxi）Co.,Ltd · 1 drug in this class
4. East Carolina University · 1 drug in this class
5. Galderma R&D · 1 drug in this class
6. Hadassah Medical Organization · 1 drug in this class
7. University of Alabama at Birmingham · 1 drug in this class
8. University of New Mexico · 1 drug in this class
9. Ain Shams University · 1 drug in this class
10. University of Wisconsin, Madison · 1 drug in this class