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Bupivacaine %0.25 (isobaric)
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Local and regional anesthesia for surgical procedures, Spinal anesthesia, Epidural anesthesia.
At a glance
| Generic name | Bupivacaine %0.25 (isobaric) |
|---|---|
| Also known as | Plain bupivacaine |
| Sponsor | Bursa City Hospital |
| Drug class | Local anesthetic (amide class) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, inhibiting sodium influx and preventing depolarization. This action halts the generation and conduction of nerve impulses in the area where it is administered. The isobaric formulation (0.25%) has a specific gravity equal to cerebrospinal fluid, making it suitable for spinal anesthesia with minimal positional effects.
Approved indications
- Local and regional anesthesia for surgical procedures
- Spinal anesthesia
- Epidural anesthesia
- Peripheral nerve blocks
Common side effects
- Hypotension
- Bradycardia
- Headache (post-dural puncture)
- Neurological toxicity (at high doses)
- Cardiac arrhythmias (systemic toxicity)
- Transient neurological symptoms
Key clinical trials
- Retrolaminar Block Versus Subcostal Transversus Abdominis Plane Block in Liver Resection Surgery (NA)
- The Effect of Epidural Anesthesia on Optic Nerve Sheath Diameter Measurements in Total Knee Prosthesis Surgery (NA)
- Vaginal Cuff Bupivacaine Injection for Postoperative Pain (NA)
- Caudal Dexmedetomidine vs Ketamine for Postoperative Analgesia in Pediatric DDH Surgery (NA)
- iPACK Block vs. Periarticular Infiltration for TKA Pain Control (NA)
- Incidence of Pruritus Using Intrathecal Fentanyl Versus Epidural Fentanyl to Initiate Labour Analgesia. (NA)
- Dexamethasone Versus Magnesium Sulphate as an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block for Postoperative Analgesia in Elective Caesarean Section Under Spinal Anesthesia (NA)
- Regional Anesthesia EMG Study (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine %0.25 (isobaric) CI brief — competitive landscape report
- Bupivacaine %0.25 (isobaric) updates RSS · CI watch RSS
- Bursa City Hospital portfolio CI