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LD: Lidocaine and dexamethasone
Lidocaine provides local anesthesia by blocking sodium channels in nerve fibers, while dexamethasone reduces inflammation and swelling at the injection or application site.
Lidocaine provides local anesthesia by blocking sodium channels in nerve fibers, while dexamethasone reduces inflammation and swelling at the injection or application site. Used for Local anesthesia with anti-inflammatory effect for injection or topical use, Pain and inflammation management in minor surgical or dental procedures.
At a glance
| Generic name | LD: Lidocaine and dexamethasone |
|---|---|
| Also known as | Xylocard, dexona |
| Sponsor | B.P. Koirala Institute of Health Sciences |
| Drug class | Local anesthetic with corticosteroid combination |
| Target | Voltage-gated sodium channels (lidocaine); glucocorticoid receptor (dexamethasone) |
| Modality | Small molecule |
| Therapeutic area | Pain management, Anesthesia, Inflammation |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that inhibits sodium influx into nerve cells, preventing depolarization and blocking pain signal transmission. Dexamethasone is a corticosteroid that suppresses inflammatory responses by inhibiting phospholipase A2 and reducing prostaglandin and cytokine production. Together, they provide both anesthetic and anti-inflammatory effects for localized pain and inflammation management.
Approved indications
- Local anesthesia with anti-inflammatory effect for injection or topical use
- Pain and inflammation management in minor surgical or dental procedures
Common side effects
- Local irritation or burning at application site
- Allergic reaction to lidocaine
- Systemic corticosteroid effects with prolonged use
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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