{"id":"ld-lidocaine-and-dexamethasone","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning at application site"},{"rate":null,"effect":"Allergic reaction to lidocaine"},{"rate":null,"effect":"Systemic corticosteroid effects with prolonged use"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lidocaine is a local anesthetic that inhibits sodium influx into nerve cells, preventing depolarization and blocking pain signal transmission. Dexamethasone is a corticosteroid that suppresses inflammatory responses by inhibiting phospholipase A2 and reducing prostaglandin and cytokine production. Together, they provide both anesthetic and anti-inflammatory effects for localized pain and inflammation management.","oneSentence":"Lidocaine provides local anesthesia by blocking sodium channels in nerve fibers, while dexamethasone reduces inflammation and swelling at the injection or application site.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:51:44.773Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia with anti-inflammatory effect for injection or topical use"},{"name":"Pain and inflammation management in minor surgical or dental procedures"}]},"trialDetails":[{"nctId":"NCT01990781","phase":"PHASE4","title":"Effect of Intravenous Lidocaine and Dexamethasone Combination on Postoperative Sore Throat, Cough and Hoarseness.","status":"COMPLETED","sponsor":"B.P. Koirala Institute of Health Sciences","startDate":"2013-12","conditions":"Postoperative Sore Throat, Cough, Hoarseness","enrollment":180}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Xylocard, dexona"],"phase":"marketed","status":"active","brandName":"LD: Lidocaine and dexamethasone","genericName":"LD: Lidocaine and dexamethasone","companyName":"B.P. Koirala Institute of Health Sciences","companyId":"b-p-koirala-institute-of-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lidocaine provides local anesthesia by blocking sodium channels in nerve fibers, while dexamethasone reduces inflammation and swelling at the injection or application site. Used for Local anesthesia with anti-inflammatory effect for injection or topical use, Pain and inflammation management in minor surgical or dental procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}