{"id":"lidocaine-chlorprocaine-combination","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Transient paresthesia"},{"rate":null,"effect":"Allergic reactions (rare with amide-ester combination)"},{"rate":null,"effect":"Systemic toxicity (at high doses)"}]},"_chembl":{"chemblId":"CHEMBL79","moleculeType":"Small molecule","molecularWeight":"234.34"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lidocaine is a fast-acting local anesthetic that rapidly blocks sodium influx in nerve membranes, while chlorprocaine is an ester local anesthetic with intermediate onset. The combination leverages lidocaine's quick onset with chlorprocaine's duration to provide both rapid anesthesia initiation and extended anesthetic coverage for surgical and procedural applications.","oneSentence":"This combination of two local anesthetics blocks sodium channels in nerve fibers to produce rapid onset and prolonged duration of local anesthesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:34:01.417Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia for surgical and procedural applications"}]},"trialDetails":[{"nctId":"NCT06302257","phase":"PHASE4","title":"Randomized Controlled Trial of Combined Lidocaine - Chlorprocaine in Labor Epidural Analgesia.","status":"NOT_YET_RECRUITING","sponsor":"Hadassah Medical Organization","startDate":"2024-03-01","conditions":"Labor Pain","enrollment":60},{"nctId":"NCT03414359","phase":"EARLY_PHASE1","title":"Comparison of Chloroprocaine vs Lidocaine for Epidural Anesthesia in Cesarean Delivery","status":"COMPLETED","sponsor":"University of Arkansas","startDate":"2018-02-15","conditions":"Surgical Anesthesia, Cesarean Section","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Lidocaine-chlorprocaine combination","genericName":"Lidocaine-chlorprocaine combination","companyName":"Hadassah Medical Organization","companyId":"hadassah-medical-organization","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination of two local anesthetics blocks sodium channels in nerve fibers to produce rapid onset and prolonged duration of local anesthesia. Used for Local and regional anesthesia for infiltration and nerve blocks.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}