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Bupivacaine plus Lidocaine
Bupivacaine and lidocaine are local anesthetics that block sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Bupivacaine and lidocaine are local anesthetics that block sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local and regional anesthesia for surgical and diagnostic procedures, Pain relief in infiltration anesthesia.
At a glance
| Generic name | Bupivacaine plus Lidocaine |
|---|---|
| Also known as | Lidoderm, Xylocaine, Recticare, Anecream, Lmx4, Akten,, Marcaine and Sensorcaine, Marcaine Xylocaine |
| Sponsor | University of Alabama at Birmingham |
| Drug class | Local anesthetic combination |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Pain Management |
| Phase | FDA-approved |
Mechanism of action
Both drugs are amide-class local anesthetics that work by inhibiting sodium influx through voltage-gated sodium channels in the neuronal cell membrane. This prevents depolarization and action potential generation, thereby blocking sensory and motor nerve conduction in a localized area. The combination formulation provides complementary pharmacokinetics, with lidocaine offering faster onset and bupivacaine providing longer duration of action.
Approved indications
- Local and regional anesthesia for surgical and diagnostic procedures
- Pain relief in infiltration anesthesia
Common side effects
- Systemic toxicity (CNS effects: tremor, seizures)
- Cardiovascular effects (hypotension, arrhythmias)
- Allergic reactions
- Local tissue irritation or necrosis
Key clinical trials
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
- Mid-transverse Process Combined With Erector Spinae Block Versus Paravertebral Plane Block (NA)
- EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement (PHASE2)
- Effect of Bilateral Rhomboid Intercostal Block on Postoperative Pain After Breast Implant Surgery (NA)
- Sacral Erector Spinae Plane Block in Transurethral Prostate Resection Surgery (NA)
- Thoracic Epidural Analgesia With Bilateral Erector Spinae Plane Block in Radical Cystectomy Surgery (NA)
- Comparison of Post-Dural Puncture Headache After Spinal Anesthesia Using Median Versus Paramedian Approach (NA)
- Prospective Evaluation of Efficacy of Tumescent Steroid Infiltration in Mandibular Third Molar Surgery: a Split Mouth Randomized Study (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine plus Lidocaine CI brief — competitive landscape report
- Bupivacaine plus Lidocaine updates RSS · CI watch RSS
- University of Alabama at Birmingham portfolio CI