{"id":"bupivacaine-plus-lidocaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Systemic toxicity (CNS effects: tremor, seizures)"},{"rate":null,"effect":"Cardiovascular effects (hypotension, arrhythmias)"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Local tissue irritation or necrosis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Both drugs are amide-class local anesthetics that work by inhibiting sodium influx through voltage-gated sodium channels in the neuronal cell membrane. This prevents depolarization and action potential generation, thereby blocking sensory and motor nerve conduction in a localized area. The combination formulation provides complementary pharmacokinetics, with lidocaine offering faster onset and bupivacaine providing longer duration of action.","oneSentence":"Bupivacaine and lidocaine are local anesthetics that block sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:29:06.088Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia for surgical and diagnostic procedures"},{"name":"Pain relief in infiltration anesthesia"}]},"trialDetails":[{"nctId":"NCT07489001","phase":"","title":"Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery","status":"RECRUITING","sponsor":"Marmara University","startDate":"2025-12-09","conditions":"Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative 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