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Epidural analgesia Ropivacaine
Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce regional anesthesia.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce regional anesthesia. Used for Epidural analgesia for postoperative pain management, Epidural anesthesia for surgical procedures.
At a glance
| Generic name | Epidural analgesia Ropivacaine |
|---|---|
| Sponsor | Universitair Ziekenhuis Brussel |
| Drug class | Local anesthetic (amide class) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes. This prevents sodium influx and depolarization, thereby inhibiting nerve impulse conduction. When administered epidurally, it produces localized anesthesia and analgesia in the distribution of the spinal nerves.
Approved indications
- Epidural analgesia for postoperative pain management
- Epidural anesthesia for surgical procedures
Common side effects
- Hypotension
- Bradycardia
- Headache
- Nausea
- Neurological toxicity (at high systemic levels)
- Cardiovascular toxicity (at high systemic levels)
Key clinical trials
- Contrast and Anesthetic Level With Lumbar Erector Spinae Plan (ESP) Block (NA)
- PAravertebral CaTheter Versus Epidural Analgesia in Totally Minimally Invasive Esophagectomies (NA)
- Comparing PIEB and CEI for Labor Pain Relief (NA)
- Ropivacaine and Fentanyl for Labor Epidural Initiation (PHASE3)
- Continuous Wound Catheter Analgesia Associated With Intravenous Morphine PCA After Thoracotomy (PHASE4)
- Paravertebral Analgesia Associated With Intravenous Morphine PCA After Thoracotomy (PHASE3)
- Effect of the PIEB Versus CEI on the Quality of Postoperative Recovery in Patients Undergoing VATS Lobectomy (NA)
- Influence of Analgesic Technique on Post Operative Rehabilitation After Median Laparotomy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Epidural analgesia Ropivacaine CI brief — competitive landscape report
- Epidural analgesia Ropivacaine updates RSS · CI watch RSS
- Universitair Ziekenhuis Brussel portfolio CI