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Lidocaine 1%/Epi 1:200000
Lidocaine 1%/Epi 1:200000 is a Local anesthetic with vasoconstrictor Small molecule drug developed by Wahba bakhet. It is currently FDA-approved for Local anesthesia for infiltration, nerve blocks, and topical procedures, Dental anesthesia, Minor surgical procedures requiring local anesthesia. Also known as: Xylocaine 1%/Epi 1:200000.
Lidocaine blocks sodium channels in nerve cell membranes to produce local anesthesia, while epinephrine causes vasoconstriction to prolong the anesthetic effect and reduce systemic absorption.
Lidocaine blocks sodium channels in nerve cell membranes to produce local anesthesia, while epinephrine causes vasoconstriction to prolong the anesthetic effect and reduce systemic absorption. Used for Local anesthesia for infiltration, nerve blocks, and topical procedures, Dental anesthesia, Minor surgical procedures requiring local anesthesia.
At a glance
| Generic name | Lidocaine 1%/Epi 1:200000 |
|---|---|
| Also known as | Xylocaine 1%/Epi 1:200000 |
| Sponsor | Wahba bakhet |
| Drug class | Local anesthetic with vasoconstrictor |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that reversibly inhibits sodium influx into nerve fibers, preventing depolarization and action potential propagation. The addition of epinephrine (1:200,000 concentration) acts as a vasconstrictor on local blood vessels, which slows the systemic absorption of lidocaine, extends its duration of action at the injection site, and reduces the risk of systemic toxicity.
Approved indications
- Local anesthesia for infiltration, nerve blocks, and topical procedures
- Dental anesthesia
- Minor surgical procedures requiring local anesthesia
Common side effects
- Injection site pain or burning
- Transient paresthesia
- Allergic reaction (rare with amide lidocaine)
- Systemic toxicity (CNS or cardiac effects at high doses)
- Headache
Key clinical trials
- Efficacy of SLN Block for Chronic Cough (PHASE3)
- Spinal Analgesia as Fast Track Painless Labor
- Infrazygomatic Versus Intranasal Injection Sphinopalatine Ganglion Blockade Effect on Surgical Field in FESS (NA)
- Study of Analgesic Efficacy of Nerve Blocks on Otoplastic Surgery (PHASE4)
- Local Anesthesia for Pediatric Cochlear Implant (PHASE4)
- Early Detection of Epidural Onset by Temperature Change (NA)
- Influence of Ultrasonographic Hydro-dissection With Glucose 5% on Nerve Block Efficiency (PHASE4)
- Pain Relief Effects on Length of Labor (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lidocaine 1%/Epi 1:200000 CI brief — competitive landscape report
- Lidocaine 1%/Epi 1:200000 updates RSS · CI watch RSS
- Wahba bakhet portfolio CI
Frequently asked questions about Lidocaine 1%/Epi 1:200000
What is Lidocaine 1%/Epi 1:200000?
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What is Lidocaine 1%/Epi 1:200000 used for?
Who makes Lidocaine 1%/Epi 1:200000?
Is Lidocaine 1%/Epi 1:200000 also known as anything else?
What drug class is Lidocaine 1%/Epi 1:200000 in?
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What are the side effects of Lidocaine 1%/Epi 1:200000?
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Related
- Drug class: All Local anesthetic with vasoconstrictor drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: Wahba bakhet — full pipeline
- Therapeutic area: All drugs in Anesthesia/Pain Management
- Indication: Drugs for Local anesthesia for infiltration, nerve blocks, and topical procedures
- Indication: Drugs for Dental anesthesia
- Indication: Drugs for Minor surgical procedures requiring local anesthesia
- Also known as: Xylocaine 1%/Epi 1:200000
- Compare: Lidocaine 1%/Epi 1:200000 vs similar drugs
- Pricing: Lidocaine 1%/Epi 1:200000 cost, discount & access