Lidocaine 1%/Epi 1:200000 — Competitive Intelligence Brief

Lidocaine 1%/Epi 1:200000 (Lidocaine 1%/Epi 1:200000) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Local anesthetic with vasoconstrictor. Area: Anesthesia/Pain Management.

marketed Local anesthetic with vasoconstrictor Voltage-gated sodium channels Anesthesia/Pain Management Small molecule

Target snapshot

Lidocaine 1%/Epi 1:200000 (Lidocaine 1%/Epi 1:200000) — Wahba bakhet. Lidocaine blocks sodium channels in nerve cell membranes to produce local anesthesia, while epinephrine causes vasoconstriction to prolong the anesthetic effect and reduce systemic absorption.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Lidocaine 1%/Epi 1:200000 TARGET	Lidocaine 1%/Epi 1:200000	Wahba bakhet	marketed	Local anesthetic with vasoconstrictor	Voltage-gated sodium channels
Exparel TAP + multi-modal pain regimen	Exparel TAP + multi-modal pain regimen	Pacira Pharmaceuticals, Inc	marketed	Local anesthetic (liposomal formulation)	Voltage-gated sodium channels
Suzetrigine (SUZ)	Suzetrigine (SUZ)	Vertex Pharmaceuticals Incorporated	marketed	Selective sodium channel inhibitor	Voltage-gated sodium channels (Nav)
Dexamethasone+ Bupivacaine	Dexamethasone+ Bupivacaine	Ain Shams University	marketed	Corticosteroid + Local anesthetic combination	Glucocorticoid receptor (dexamethasone); Voltage-gated sodium channels (bupivacaine)
carbamazepine ER (Equetro)	carbamazepine ER (Equetro)	Massachusetts General Hospital	marketed	Anticonvulsant; mood stabilizer	Voltage-gated sodium channels
All registered antiepileptic drugs	All registered antiepileptic drugs	UMC Utrecht	marketed	Antiepileptic drugs (heterogeneous class)	Multiple targets including voltage-gated sodium channels, GABA receptors, calcium channels, SV2A, and others depending on specific agent
Bupivacaine Spinal 0,5% Heavy - bolus	Bupivacaine Spinal 0,5% Heavy - bolus	Centre of Postgraduate Medical Education	marketed	Local anesthetic (amide class)	Voltage-gated sodium channels

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Local anesthetic with vasoconstrictor class)

1. Ankara Yildirim Beyazıt University · 1 drug in this class
2. Health Sciences North Research Institute · 1 drug in this class
3. Ohio State University · 1 drug in this class
4. Pontificia Universidad Catolica de Chile · 1 drug in this class
5. University Hospital, Antwerp · 1 drug in this class
6. University of Wisconsin, Madison · 1 drug in this class
7. Vrije Universiteit Brussel · 1 drug in this class
8. Wahba bakhet · 1 drug in this class
9. Weill Medical College of Cornell University · 1 drug in this class