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Bupivacaine Spinal 0,5% Heavy - bolus
Bupivacaine Spinal 0,5% Heavy - bolus is a Local anesthetic (amide class) Small molecule drug developed by Centre of Postgraduate Medical Education. It is currently FDA-approved for Spinal anesthesia for surgical procedures of the lower abdomen, pelvis, and lower extremities, Spinal anesthesia for obstetric procedures. Also known as: Single bolus.
Bupivacaine blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce local anesthesia.
Bupivacaine blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce local anesthesia. Used for Spinal anesthesia for surgical procedures of the lower abdomen, pelvis, and lower extremities, Spinal anesthesia for obstetric procedures.
At a glance
| Generic name | Bupivacaine Spinal 0,5% Heavy - bolus |
|---|---|
| Also known as | Single bolus |
| Sponsor | Centre of Postgraduate Medical Education |
| Drug class | Local anesthetic (amide class) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting local anesthetic that penetrates nerve membranes and reversibly binds to sodium channels from the intracellular side, inhibiting sodium influx and depolarization. The 0.5% heavy formulation (isobaric or hyperbaric depending on preparation) is administered intrathecally for spinal anesthesia, providing prolonged sensory and motor blockade in the lower body and lower extremities. The 'heavy' designation typically indicates the solution is hyperbaric (denser than cerebrospinal fluid), affecting its distribution in the spinal canal.
Approved indications
- Spinal anesthesia for surgical procedures of the lower abdomen, pelvis, and lower extremities
- Spinal anesthesia for obstetric procedures
Common side effects
- Hypotension
- Bradycardia
- Headache (post-dural puncture)
- Nausea
- Urinary retention
- Transient neurological symptoms
- Back pain
Key clinical trials
- Spinal Anesthesia For Enhanced Recovery After Liver Surgery (NA)
- Lumbar ESPB in Hip Replacement Surgery (NA)
- Different Noradrenaline Protocols in Post Spinal Hypotension in CS (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine Spinal 0,5% Heavy - bolus CI brief — competitive landscape report
- Bupivacaine Spinal 0,5% Heavy - bolus updates RSS · CI watch RSS
- Centre of Postgraduate Medical Education portfolio CI
Frequently asked questions about Bupivacaine Spinal 0,5% Heavy - bolus
What is Bupivacaine Spinal 0,5% Heavy - bolus?
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What is Bupivacaine Spinal 0,5% Heavy - bolus used for?
Who makes Bupivacaine Spinal 0,5% Heavy - bolus?
Is Bupivacaine Spinal 0,5% Heavy - bolus also known as anything else?
What drug class is Bupivacaine Spinal 0,5% Heavy - bolus in?
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What does Bupivacaine Spinal 0,5% Heavy - bolus target?
Related
- Drug class: All Local anesthetic (amide class) drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: Centre of Postgraduate Medical Education — full pipeline
- Therapeutic area: All drugs in Anesthesiology
- Indication: Drugs for Spinal anesthesia for surgical procedures of the lower abdomen, pelvis, and lower extremities
- Indication: Drugs for Spinal anesthesia for obstetric procedures
- Also known as: Single bolus
- Compare: Bupivacaine Spinal 0,5% Heavy - bolus vs similar drugs
- Pricing: Bupivacaine Spinal 0,5% Heavy - bolus cost, discount & access