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Dexamethasone+ Bupivacaine
Dexamethasone reduces inflammation and immune response while bupivacaine provides local anesthesia by blocking nerve conduction.
Dexamethasone reduces inflammation and immune response while bupivacaine provides local anesthesia by blocking nerve conduction. Used for Local anesthesia with anti-inflammatory effect for regional anesthesia and pain management, Periarticular or perineural injection to reduce postoperative pain and inflammation.
At a glance
| Generic name | Dexamethasone+ Bupivacaine |
|---|---|
| Sponsor | Ain Shams University |
| Drug class | Corticosteroid + Local anesthetic combination |
| Target | Glucocorticoid receptor (dexamethasone); Voltage-gated sodium channels (bupivacaine) |
| Modality | Small molecule |
| Therapeutic area | Pain management, Anesthesia, Inflammation |
| Phase | FDA-approved |
Mechanism of action
Dexamethasone is a corticosteroid that suppresses inflammatory and immune responses by inhibiting phospholipase A2 and reducing prostaglandin and leukotriene production. Bupivacaine is a local anesthetic that blocks sodium channels in nerve membranes, preventing action potential propagation. Together, this combination provides both local pain relief and anti-inflammatory effects at the injection site.
Approved indications
- Local anesthesia with anti-inflammatory effect for regional anesthesia and pain management
- Periarticular or perineural injection to reduce postoperative pain and inflammation
Common side effects
- Local injection site reactions
- Transient nerve irritation
- Systemic corticosteroid effects (with repeated use)
- Allergic reactions to bupivacaine
Key clinical trials
- Arthrosemid vs. Steroid for the Management Knee Osteoarthritis (PHASE4)
- Comparison of Intrathecal Morphine and Rectus Sheath Block for Postoperative Pain Management After Lower Abdominal Surgery With Midline Incision (NA)
- Comparison Between Dexamethasone and Dexmedetomidine in Spinal Anesthesia for Cases With Fracture Pelvis Fixation (EARLY_PHASE1)
- Postoperative Pain Monitoring With ANI in Lumbar Spine Surgery (NA)
- Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty (NA)
- Thoracic Epidural Analgesia With Bilateral Erector Spinae Plane Block in Radical Cystectomy Surgery (NA)
- ESP Block VS Intrathecal Opioid After Laparoscopic Colorectal Surgery (PHASE1, PHASE2)
- Prospective Evaluation of Efficacy of Tumescent Steroid Infiltration in Mandibular Third Molar Surgery: a Split Mouth Randomized Study (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Dexamethasone+ Bupivacaine CI brief — competitive landscape report
- Dexamethasone+ Bupivacaine updates RSS · CI watch RSS
- Ain Shams University portfolio CI