What are Local anesthetic with vasoconstrictor drugs?

Local anesthetic with vasoconstrictor drugs are pharmacologic agents that share a common mechanism (typically targeting Voltage-gated sodium channels; alpha-1 adrenergic receptors (epinephrine component)). 9 are currently marketed, with 0 more in clinical development.

What are the marketed Local anesthetic with vasoconstrictor drugs?

Marketed Local anesthetic with vasoconstrictor drugs include Buffered Articaine Hydrochloride + Epinephrine, Articaine Hydrochloride + Epinephrine, Tumescent Solution with dilute epinephrine, Ropivicaine with Epinephrine, lidocaine + epinephrine 1:100,000, Levobupivacaine with epinephrine.

Local anesthetic with vasoconstrictor

9 marketed

This page covers all Local anesthetic with vasoconstrictor drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Voltage-gated sodium channels; alpha-1 adrenergic receptors (epinephrine component), Voltage-gated sodium channels, Voltage-gated sodium channels (lidocaine); alpha-1 and beta-1 adrenergic receptors (epinephrine).

Targets

Voltage-gated sodium channels; alpha-1 adrenergic receptors (epinephrine component) · Voltage-gated sodium channels · Voltage-gated sodium channels (lidocaine); alpha-1 and beta-1 adrenergic receptors (epinephrine) · Voltage-gated sodium channels; alpha-1 adrenergic receptors · Voltage-gated sodium channels; alpha-adrenergic receptors

Marketed (9)

Buffered Articaine Hydrochloride + Epinephrine · Ohio State University · Anesthesiology / Dentistry
Buffered articaine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes, while epinephrine is a vasoconstrictor that prolongs anesthetic duration and reduces bleeding.
Articaine Hydrochloride + Epinephrine · Ankara Yildirim Beyazıt University · Anesthesia / Dentistry
Articaine is a local anesthetic that blocks sodium channels in nerve membranes, while epinephrine is a vasoconstrictor that prolongs anesthetic duration and reduces bleeding.
Tumescent Solution with dilute epinephrine · University of Wisconsin, Madison · Surgery/Anesthesia
Tumescent solution with dilute epinephrine provides local anesthesia and hemostasis by infiltrating tissue with lidocaine and vasoconstricting blood vessels through epinephrine, reducing bleeding and allowing safer surgical procedures.
Ropivicaine with Epinephrine · Health Sciences North Research Institute · Anesthesia/Pain Management
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission, while epinephrine is a vasoconstrictor that prolongs the anesthetic's duration and reduces systemic absorption.
lidocaine + epinephrine 1:100,000 · Weill Medical College of Cornell University · Anesthesia
Lidocaine blocks sodium channels to provide local anesthesia, while epinephrine causes vasoconstriction to prolong anesthetic duration and reduce systemic toxicity.
Levobupivacaine with epinephrine · Pontificia Universidad Catolica de Chile · Anesthesia
Levobupivacaine blocks sodium channels in nerve cell membranes to produce local anesthesia, while epinephrine causes vasoconstriction to prolong the anesthetic effect and reduce systemic absorption.
Xylocaine with Epinephrine · Vrije Universiteit Brussel · Anesthesia
Xylocaine (lidocaine) blocks sodium channels to produce local anesthesia, while epinephrine causes vasoconstriction to prolong anesthetic duration and reduce systemic absorption.
Lidocaine 1%/Epi 1:200000 · Wahba bakhet · Anesthesia/Pain Management
Lidocaine blocks sodium channels in nerve cell membranes to produce local anesthesia, while epinephrine causes vasoconstriction to prolong the anesthetic effect and reduce systemic absorption.
Levobupivacaine 0.5% + epinephrin 1/200000 · University Hospital, Antwerp · Anesthesia
Levobupivacaine blocks sodium channels in nerve cell membranes to produce local anesthesia, while epinephrine causes vasoconstriction to prolong the anesthetic effect and reduce systemic absorption.