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Articaine Hydrochloride + Epinephrine
Articaine is a local anesthetic that blocks sodium channels in nerve membranes, while epinephrine is a vasoconstrictor that prolongs anesthetic duration and reduces bleeding.
Articaine is a local anesthetic that blocks sodium channels in nerve membranes, while epinephrine is a vasoconstrictor that prolongs anesthetic duration and reduces bleeding. Used for Local and regional anesthesia for dental procedures, Infiltration anesthesia for minor surgical procedures.
At a glance
| Generic name | Articaine Hydrochloride + Epinephrine |
|---|---|
| Also known as | ultracaine ds, local anesthetic |
| Sponsor | Ankara Yildirim Beyazıt University |
| Drug class | Local anesthetic with vasoconstrictor |
| Target | Voltage-gated sodium channels; alpha-1 adrenergic receptors (epinephrine component) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Dentistry |
| Phase | FDA-approved |
Mechanism of action
Articaine hydrochloride works by reversibly inhibiting sodium influx into nerve cells, preventing depolarization and action potential propagation. The addition of epinephrine causes vasoconstriction of local blood vessels, which slows systemic absorption of the anesthetic, extends its duration of action, and reduces local bleeding during procedures.
Approved indications
- Local and regional anesthesia for dental procedures
- Infiltration anesthesia for minor surgical procedures
Common side effects
- Paresthesia
- Nerve injury
- Allergic reaction
- Cardiovascular effects (from epinephrine)
- Methemoglobinemia (rare)
Key clinical trials
- Effects of Local Ketamine in Orthognathic Procedures (NA)
- Radiographic and Histological Assessment of GBR Using DBB Compared to Spontaneous Bone Regeneration of Maxillary Defects , Resulted From Enucleation of Intra-bony Cystic Lesions (NA)
- Clinical Outcomes of Mandibular Primary Molar Extraction Using Physics Forceps in Children (NA)
- Comparison of Anesthetic Efficacy OF 2% Lidocaine Inferior Alveolar Nerve (IANB) Block Versus Primary Buccal Infilteration With 4% Articaine in Symptomatic Irreversible Pulpitis(SIP) IN Mandibular First Molars (NA)
- 'Propolis Versus Chlorhexidine Gluconate on Wound Healing After Third Molar Surgery: a Randomized Controlled Trial' (NA)
- Preemptive Analgesia for Pain and Anxiety Control in Children With MIH (NA)
- Investigation of the Effect of Horizontal Platelet Rich Fibrin Placed in Tooth Extraction Sockets on Bone Formation (NA)
- Investigation of the Effects of H-PRF on the Period After Impacted Third Molar Tooth Extraction (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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