Last reviewed · How we verify
Xylocaine with Epinephrine
Xylocaine (lidocaine) blocks sodium channels to produce local anesthesia, while epinephrine causes vasoconstriction to prolong anesthetic duration and reduce systemic absorption.
Xylocaine (lidocaine) blocks sodium channels to produce local anesthesia, while epinephrine causes vasoconstriction to prolong anesthetic duration and reduce systemic absorption. Used for Local and regional anesthesia for surgical and dental procedures, Infiltration anesthesia, Nerve blocks.
At a glance
| Generic name | Xylocaine with Epinephrine |
|---|---|
| Also known as | Subconjucntival injection with xylocain injection |
| Sponsor | Vrije Universiteit Brussel |
| Drug class | Local anesthetic with vasoconstrictor |
| Target | Voltage-gated sodium channels; alpha-1 adrenergic receptors |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that reversibly inhibits sodium influx through nerve cell membranes, preventing depolarization and conduction of nerve impulses. Epinephrine is a sympathomimetic agent that causes vasoconstriction of local blood vessels, which slows the rate of lidocaine absorption into the systemic circulation, thereby extending the duration of anesthesia and reducing toxicity risk.
Approved indications
- Local and regional anesthesia for surgical and dental procedures
- Infiltration anesthesia
- Nerve blocks
Common side effects
- Lightheadedness or dizziness
- Nervousness or anxiety
- Tremor
- Palpitations or tachycardia
- Allergic reactions (rare)
Key clinical trials
- Jaw Muscle Pain Post Wisdom Molar Surgery (PHASE2)
- Single Gene Polymorphism and the Success Rate of Inferior Alveolar Nerve Block (NA)
- Mid-transverse Process Combined With Erector Spinae Block Versus Paravertebral Plane Block (NA)
- This Clinical Trial Aims to Compare the Effectiveness of Two Intra-pulpal Cryotherapy Techniques-Endo-ice and Ice Sticks-in Decreasing Intra-operative Pain and Enhancing the Success of Local Anesthesia During Pulpectomy of Mandibular Molars With Symptomatic Irreversible Pulpitis. (NA)
- A Study to Determine the Safety and Effectiveness of a Connective Tissue Allograft (ActiveMatrix) Verses Standard of Care in Adhesive Capsulitis of the Shoulder (PHASE4)
- Reducing Side-effects of Autologous Skin Tissue Harvesting (EARLY_PHASE1)
- Prospective Evaluation of Efficacy of Tumescent Steroid Infiltration in Mandibular Third Molar Surgery: a Split Mouth Randomized Study (NA)
- Management of Epistaxis Comparing Nasal Packing Versus Greater Palatine Foramen Block (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Xylocaine with Epinephrine CI brief — competitive landscape report
- Xylocaine with Epinephrine updates RSS · CI watch RSS
- Vrije Universiteit Brussel portfolio CI