Xylocaine with Epinephrine — Competitive Intelligence Brief

Xylocaine with Epinephrine (Xylocaine with Epinephrine) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Local anesthetic with vasoconstrictor. Area: Anesthesia.

marketed Local anesthetic with vasoconstrictor Voltage-gated sodium channels; alpha-1 adrenergic receptors Anesthesia Small molecule

Target snapshot

Xylocaine with Epinephrine (Xylocaine with Epinephrine) — Vrije Universiteit Brussel. Xylocaine (lidocaine) blocks sodium channels to produce local anesthesia, while epinephrine causes vasoconstriction to prolong anesthetic duration and reduce systemic absorption.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Xylocaine with Epinephrine TARGET	Xylocaine with Epinephrine	Vrije Universiteit Brussel	marketed	Local anesthetic with vasoconstrictor	Voltage-gated sodium channels; alpha-1 adrenergic receptors
Levobupivacaine with epinephrine	Levobupivacaine with epinephrine	Pontificia Universidad Catolica de Chile	marketed	Local anesthetic with vasoconstrictor	Voltage-gated sodium channels; alpha-1 adrenergic receptors (epinephrine component)
Bupivacaine-adrenaline	Bupivacaine-adrenaline	University of Aarhus	marketed	Local anesthetic with vasopressor	Voltage-gated sodium channels; alpha-1 adrenergic receptors (adrenaline component)
Buffered Articaine Hydrochloride + Epinephrine	Buffered Articaine Hydrochloride + Epinephrine	Ohio State University	marketed	Local anesthetic with vasoconstrictor	Voltage-gated sodium channels; alpha-1 adrenergic receptors (epinephrine component)
Articaine Hydrochloride + Epinephrine	Articaine Hydrochloride + Epinephrine	Ankara Yildirim Beyazıt University	marketed	Local anesthetic with vasoconstrictor	Voltage-gated sodium channels; alpha-1 adrenergic receptors (epinephrine component)
Ropivicaine with Epinephrine	Ropivicaine with Epinephrine	Health Sciences North Research Institute	marketed	Local anesthetic with vasoconstrictor	Voltage-gated sodium channels
Levobupivacaine 0.5% + epinephrin 1/200000	Levobupivacaine 0.5% + epinephrin 1/200000	University Hospital, Antwerp	marketed	Local anesthetic with vasoconstrictor	Voltage-gated sodium channels; alpha-adrenergic receptors

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Local anesthetic with vasoconstrictor class)

1. Ankara Yildirim Beyazıt University · 1 drug in this class
2. Health Sciences North Research Institute · 1 drug in this class
3. Ohio State University · 1 drug in this class
4. Pontificia Universidad Catolica de Chile · 1 drug in this class
5. University Hospital, Antwerp · 1 drug in this class
6. University of Wisconsin, Madison · 1 drug in this class
7. Vrije Universiteit Brussel · 1 drug in this class
8. Wahba bakhet · 1 drug in this class
9. Weill Medical College of Cornell University · 1 drug in this class