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Levobupivacaine with epinephrine
Levobupivacaine blocks sodium channels in nerve cell membranes to produce local anesthesia, while epinephrine causes vasoconstriction to prolong the anesthetic effect and reduce systemic absorption.
Levobupivacaine blocks sodium channels in nerve cell membranes to produce local anesthesia, while epinephrine causes vasoconstriction to prolong the anesthetic effect and reduce systemic absorption. Used for Local and regional anesthesia for surgical and diagnostic procedures, Infiltration anesthesia, Nerve blocks.
At a glance
| Generic name | Levobupivacaine with epinephrine |
|---|---|
| Sponsor | Pontificia Universidad Catolica de Chile |
| Drug class | Local anesthetic with vasoconstrictor |
| Target | Voltage-gated sodium channels; alpha-1 adrenergic receptors (epinephrine component) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Levobupivacaine is the S-enantiomer of bupivacaine, a long-acting local anesthetic that reversibly inhibits sodium influx into nerve fibers, preventing depolarization and action potential propagation. Epinephrine acts as an alpha-1 adrenergic agonist, causing vasoconstriction at the injection site that slows drug clearance, extends duration of action, and reduces peak plasma concentrations of the local anesthetic.
Approved indications
- Local and regional anesthesia for surgical and diagnostic procedures
- Infiltration anesthesia
- Nerve blocks
Common side effects
- Transient neurological symptoms
- Hypotension
- Bradycardia
- Headache
- Nausea
- Allergic reactions
Key clinical trials
- Ultrasound-Guided Quadro-Iliac Plane Block for Pain Management After Total Hip Arthroplasty (NA)
- Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy (NA)
- Comparing General Anesthesia With Single Injection Peribulbar Block With 3 Different Drugs (NA)
- Sensorimotor Block Dynamics and Hemidiaphragmatic Palsy: Selective Trunk Block vs Supraclavicular Brachial Plexus Block (NA)
- Prospective RCT Lidocaine & Levobupivacaine on Block Dynamics After Subparaneural Popliteal Sciatic Nerve Block (PHASE4)
- PK/PD Levobupivacaine with and Without Epinephrine After Ultrasound Guided ESP Block (PHASE4)
- Selective Trunk Block vs Hybrid Interscalene Supraclavicular BPB for Anaesthesia of the Entire Upper Extremity (NA)
- Comparison of Intratechal Levobupivacaine and Adding With Sufetanil and Fentanyl in Ceserean Section (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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