Last reviewed 2026-04-22 · How we verify

Buffered Articaine Hydrochloride + Epinephrine

Buffered articaine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes, while epinephrine is a vasoconstrictor that prolongs anesthetic duration and reduces bleeding.

Buffered articaine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes, while epinephrine is a vasoconstrictor that prolongs anesthetic duration and reduces bleeding. Used for Local and regional anesthesia for dental and oral surgical procedures.

At a glance

Mechanism of action

Articaine is an amide-type local anesthetic that reversibly inhibits sodium influx into nerve cells, preventing depolarization and action potential propagation. The addition of epinephrine causes vasoconstriction of local blood vessels, which slows systemic absorption of the anesthetic, extends its duration of action, and reduces intraoperative bleeding. Buffering the solution optimizes pH to enhance onset speed and efficacy.

Approved indications

• Local and regional anesthesia for dental and oral surgical procedures

Common side effects

• Injection site pain or discomfort
• Transient paresthesia
• Allergic reaction (rare with amides)
• Cardiovascular effects from epinephrine (tachycardia, hypertension)

Key clinical trials

• Comparative Evaluation of the Effect of pH Adjustment of the Solution of Articaine With Epinephrine on the Efficacy of Jet Anesthesia (NA)
• Combination of Buffered Anesthetic to Treat Mandibular Molars (PHASE4)
• Effectiveness of Sodium Bicarbonate Buffered Anaesthetic Solution on Pain During Injection (NA)
• Testing the Anesthetic Effectiveness of Buffered Articaine Injected Next to a Lower First Molar. (PHASE4)

Primary sources

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