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Ropivicaine with Epinephrine
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission, while epinephrine is a vasoconstrictor that prolongs the anesthetic's duration and reduces systemic absorption.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission, while epinephrine is a vasoconstrictor that prolongs the anesthetic's duration and reduces systemic absorption. Used for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks.
At a glance
| Generic name | Ropivicaine with Epinephrine |
|---|---|
| Sponsor | Health Sciences North Research Institute |
| Drug class | Local anesthetic with vasoconstrictor |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine reversibly inhibits sodium influx into nerve fibers, stabilizing the neuronal membrane and preventing depolarization and propagation of action potentials. Epinephrine causes vasoconstriction of local blood vessels, which slows the systemic absorption of ropivacaine, extending its local anesthetic effect and reducing the risk of systemic toxicity.
Approved indications
- Local and regional anesthesia for surgical procedures
- Infiltration anesthesia
- Nerve blocks
- Epidural anesthesia
Common side effects
- Hypertension
- Tachycardia
- Headache
- Nausea
- Dizziness
- Local site reactions (pain, erythema)
Key clinical trials
- Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
- Randomized Controlled Trial for Ankle Fracture Pain Control (PHASE4)
- Peri-operative Use of a Pain Injection in Pediatric Patients With Cerebral Palsy (PHASE4)
- Paravertebral Block for Improvement of Quality of Recovery Following Cardiac Surgery (NA)
- Lower Extremity Regional Anesthesia and Infrainguinal Bypass Grafting
- How Does the Addition of Adductor Canal Block to Local Infiltration Affect Recovery in Patients Undergoing Total Knee Arthroplasty? A Feasibility Study. (NA)
- Mesenchymal Stem Cell Therapy for Knee Osteoarthritis (PHASE1, PHASE2)
- Comparison of TAP, Anterior QL, or ESP Block for Elective Cesarean Section (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ropivicaine with Epinephrine CI brief — competitive landscape report
- Ropivicaine with Epinephrine updates RSS · CI watch RSS
- Health Sciences North Research Institute portfolio CI