Ropivicaine with Epinephrine — Competitive Intelligence Brief

Ropivicaine with Epinephrine (Ropivicaine with Epinephrine) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Local anesthetic with vasoconstrictor. Area: Anesthesia/Pain Management.

marketed Local anesthetic with vasoconstrictor Voltage-gated sodium channels Anesthesia/Pain Management Small molecule

Target snapshot

Ropivicaine with Epinephrine (Ropivicaine with Epinephrine) — Health Sciences North Research Institute. Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission, while epinephrine is a vasoconstrictor that prolongs the anesthetic's duration and reduces systemic absorption.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Ropivicaine with Epinephrine TARGET	Ropivicaine with Epinephrine	Health Sciences North Research Institute	marketed	Local anesthetic with vasoconstrictor	Voltage-gated sodium channels
Exparel TAP + multi-modal pain regimen	Exparel TAP + multi-modal pain regimen	Pacira Pharmaceuticals, Inc	marketed	Local anesthetic (liposomal formulation)	Voltage-gated sodium channels
ESL	ESL	Bial - Portela C S.A.	marketed	Voltage-gated sodium channel blocker; anticonvulsant	Voltage-gated sodium channels (Nav)
intraarticular injection with ropivacaine	intraarticular injection with ropivacaine	Hvidovre University Hospital	marketed	Local anesthetic	Voltage-gated sodium channels
Hyperbaric bupivacaine+Morphine	Hyperbaric bupivacaine+Morphine	Fundación Pública Andaluza Progreso y Salud	marketed	Local anesthetic + opioid combination	Voltage-gated sodium channels (bupivacaine); mu opioid receptors (morphine)
Exparel/bupivacaine mixture	Exparel/bupivacaine mixture	Wake Forest University Health Sciences	marketed	Local anesthetic (liposomal formulation)	Voltage-gated sodium channels
Exparel + Bupivacaine	Exparel + Bupivacaine	Pacira Pharmaceuticals, Inc	marketed	Local anesthetic (liposomal formulation)	Voltage-gated sodium channels

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Local anesthetic with vasoconstrictor class)

1. Ankara Yildirim Beyazıt University · 1 drug in this class
2. Health Sciences North Research Institute · 1 drug in this class
3. Ohio State University · 1 drug in this class
4. Pontificia Universidad Catolica de Chile · 1 drug in this class
5. University Hospital, Antwerp · 1 drug in this class
6. University of Wisconsin, Madison · 1 drug in this class
7. Vrije Universiteit Brussel · 1 drug in this class
8. Wahba bakhet · 1 drug in this class
9. Weill Medical College of Cornell University · 1 drug in this class