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Hyperbaric bupivacaine+Morphine
Hyperbaric bupivacaine+Morphine is a Local anesthetic + opioid combination Small molecule drug developed by Fundación Pública Andaluza Progreso y Salud. It is currently FDA-approved for Spinal anesthesia for surgical procedures, Postoperative pain management. Also known as: Morphine.
This combination uses bupivacaine (a local anesthetic) formulated as a hyperbaric solution with morphine (an opioid analgesic) to provide prolonged spinal anesthesia and analgesia.
This combination uses bupivacaine (a local anesthetic) formulated as a hyperbaric solution with morphine (an opioid analgesic) to provide prolonged spinal anesthesia and analgesia. Used for Spinal anesthesia for surgical procedures, Postoperative pain management.
At a glance
| Generic name | Hyperbaric bupivacaine+Morphine |
|---|---|
| Also known as | Morphine |
| Sponsor | Fundación Pública Andaluza Progreso y Salud |
| Drug class | Local anesthetic + opioid combination |
| Target | Voltage-gated sodium channels (bupivacaine); mu opioid receptors (morphine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Pain Management |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine blocks sodium channels in nerve fibers, preventing action potential propagation and producing local anesthesia. The hyperbaric formulation (denser than cerebrospinal fluid) allows controlled distribution in the spinal canal. Morphine, an opioid agonist at mu receptors in the spinal cord, provides additional analgesia and extends the duration of pain relief. Together, they produce synergistic anesthetic and analgesic effects for surgical procedures.
Approved indications
- Spinal anesthesia for surgical procedures
- Postoperative pain management
Common side effects
- Hypotension
- Bradycardia
- Nausea and vomiting
- Urinary retention
- Pruritus
- Respiratory depression
Key clinical trials
- Quality of Postoperative Analgesia and Functional Recovery After Elective Cesarean Delivery (NA)
- Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty (NA)
- Maternal Satisfaction After Spinal Anesthesia for Cesarean Delivery
- Intrathecal Morphine Versus Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection. (PHASE3)
- Spinal Anesthesia For Enhanced Recovery After Liver Surgery (NA)
- Intrathecal MoRphine Versus Transabdominal Plane Block (TAP) Block for AnalGesic Management in Elective Caesarean Section (PHASE4)
- Intrathecal Dexamethasone and Atropine on Morphine Induced Post-operative Nausea and Vomiting on Caesarean Section (NA)
- Intrathecal Dexmedetomidine vs Epinephrine (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Hyperbaric bupivacaine+Morphine CI brief — competitive landscape report
- Hyperbaric bupivacaine+Morphine updates RSS · CI watch RSS
- Fundación Pública Andaluza Progreso y Salud portfolio CI
Frequently asked questions about Hyperbaric bupivacaine+Morphine
What is Hyperbaric bupivacaine+Morphine?
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Who makes Hyperbaric bupivacaine+Morphine?
Is Hyperbaric bupivacaine+Morphine also known as anything else?
What drug class is Hyperbaric bupivacaine+Morphine in?
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What does Hyperbaric bupivacaine+Morphine target?
Related
- Drug class: All Local anesthetic + opioid combination drugs
- Target: All drugs targeting Voltage-gated sodium channels (bupivacaine); mu opioid receptors (morphine)
- Manufacturer: Fundación Pública Andaluza Progreso y Salud — full pipeline
- Therapeutic area: All drugs in Anesthesia / Pain Management
- Indication: Drugs for Spinal anesthesia for surgical procedures
- Indication: Drugs for Postoperative pain management
- Also known as: Morphine
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing