{"id":"ropivicaine-with-epinephrine","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Local site reactions (pain, erythema)"}]},"_chembl":{"chemblId":"CHEMBL1256958","moleculeType":"Small molecule","molecularWeight":"333.29"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ropivacaine reversibly inhibits sodium influx into nerve fibers, stabilizing the neuronal membrane and preventing depolarization and propagation of action potentials. Epinephrine causes vasoconstriction of local blood vessels, which slows the systemic absorption of ropivacaine, extending its local anesthetic effect and reducing the risk of systemic toxicity.","oneSentence":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission, while epinephrine is a vasoconstrictor that prolongs the anesthetic's duration and reduces systemic absorption.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:06:03.907Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia for surgical procedures"},{"name":"Infiltration anesthesia"},{"name":"Nerve blocks"},{"name":"Epidural anesthesia"}]},"trialDetails":[{"nctId":"NCT05488847","phase":"PHASE4","title":"Opioid-Free Pain Protocol After Shoulder Arthroplasty","status":"ACTIVE_NOT_RECRUITING","sponsor":"Henry Ford Health System","startDate":"2022-06-25","conditions":"Shoulder Arthropathy, Shoulder Pain","enrollment":83},{"nctId":"NCT03696199","phase":"PHASE4","title":"Randomized Controlled Trial for Ankle Fracture Pain Control","status":"RECRUITING","sponsor":"Lahey Clinic","startDate":"2020-09-01","conditions":"Ankle Fractures","enrollment":70},{"nctId":"NCT04074265","phase":"PHASE4","title":"Peri-operative Use of a Pain Injection in Pediatric Patients With Cerebral Palsy","status":"COMPLETED","sponsor":"University of California, Los Angeles","startDate":"2019-12-01","conditions":"Cerebral Palsy, Hip Dysplasia, Pain, Postoperative","enrollment":34},{"nctId":"NCT06008821","phase":"NA","title":"Paravertebral Block for Improvement of Quality of Recovery Following Cardiac Surgery","status":"UNKNOWN","sponsor":"University of British Columbia","startDate":"2023-10-13","conditions":"Post-operative Pain, Post-cardiac Surgery, Cardiac Disease","enrollment":224},{"nctId":"NCT01803165","phase":"","title":"Lower Extremity Regional Anesthesia and Infrainguinal Bypass Grafting","status":"WITHDRAWN","sponsor":"University of Nebraska","startDate":"2013-05","conditions":"Peripheral Vascular Disease","enrollment":""},{"nctId":"NCT04648072","phase":"NA","title":"How Does the Addition of Adductor Canal Block to Local Infiltration Affect Recovery in Patients Undergoing Total Knee Arthroplasty? A Feasibility Study.","status":"COMPLETED","sponsor":"Health Sciences North Research Institute","startDate":"2020-11-04","conditions":"Knee Osteoarthritis, Arthritis Knee, Knee Disease","enrollment":60},{"nctId":"NCT05288725","phase":"PHASE1, PHASE2","title":"Mesenchymal Stem Cell Therapy for Knee Osteoarthritis","status":"UNKNOWN","sponsor":"Next Generation Regenerative Medicine LLC","startDate":"2022-08","conditions":"Osteoarthritis, Knee","enrollment":120},{"nctId":"NCT03695172","phase":"PHASE4","title":"Comparison of TAP, Anterior QL, or ESP Block for Elective Cesarean Section","status":"TERMINATED","sponsor":"Duke University","startDate":"2019-09-12","conditions":"Pain, Postoperative, Cesarean Section","enrollment":12},{"nctId":"NCT04282239","phase":"NA","title":"Pectoral Nerves Block to Relieve Post-sternotomy Pain After Cardiac Surgery","status":"WITHDRAWN","sponsor":"NYU Langone Health","startDate":"2021-03-01","conditions":"Pain, Postoperative, Cardiac Surgery","enrollment":""},{"nctId":"NCT02603900","phase":"PHASE4","title":"Adductor Canal Catheter vs Local Infiltration of Analgesia for Total Knee Arthroplasty","status":"WITHDRAWN","sponsor":"Thomas Jefferson University","startDate":"2015-10","conditions":"Acute Pain, Regional Anesthesia Morbidity","enrollment":""},{"nctId":"NCT03586934","phase":"PHASE3","title":"Multimodal Analgesia in Shoulder Arthroplasty","status":"WITHDRAWN","sponsor":"Rush University Medical Center","startDate":"2018-06-01","conditions":"Shoulder Pain, Opioid Use","enrollment":""},{"nctId":"NCT02643563","phase":"NA","title":"Analgesic Duration of Long Acting Local Anesthetics for Low Volume Ultrasound-guided Interscalene Brachial Plexus Block","status":"COMPLETED","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2016-01","conditions":"Brachial Plexus Block, Anesthetics, Local","enrollment":60},{"nctId":"NCT02365961","phase":"PHASE4","title":"Hip Scope Fascia-iliaca (FI) Block Study","status":"COMPLETED","sponsor":"The Hawkins Foundation","startDate":"2015-04","conditions":"Hip Dysplasia, Femoroacetabular Impingement, Acetabular Labrum Tear","enrollment":84},{"nctId":"NCT02474654","phase":"PHASE4","title":"Implementation of a Pain Management Protocol for Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Health Sciences North Research Institute","startDate":"2015-07","conditions":"Knee Replacement, Total","enrollment":220},{"nctId":"NCT02299349","phase":"NA","title":"Bupivacaine Liposome Suspension Versus a Concentrated Multi Drug Periarticular Injection","status":"COMPLETED","sponsor":"TriHealth Inc.","startDate":"2013-08","conditions":"Total Knee Arthroplasty","enrollment":70},{"nctId":"NCT02658149","phase":"PHASE4","title":"Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty","status":"COMPLETED","sponsor":"Corewell Health East","startDate":"2016-05","conditions":"Osteoarthritis, Arthroplasty","enrollment":100},{"nctId":"NCT01759407","phase":"PHASE2","title":"Femoral Nerve Block for Femur Fracture Repair in Pediatrics","status":"TERMINATED","sponsor":"Nationwide Children's Hospital","startDate":"2013-05","conditions":"Traumatic Femur Fracture","enrollment":19},{"nctId":"NCT01667445","phase":"PHASE4","title":"Evaluation of the Use of Spinal Epimorph in Total Knee Arthroplasty","status":"COMPLETED","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2012-09","conditions":"Post-operative Pain, Osteoarthritis","enrollment":113},{"nctId":"NCT00869037","phase":"PHASE4","title":"Analgesia After Total Knee Arthroplasty","status":"UNKNOWN","sponsor":"University of Manitoba","startDate":"2009-03","conditions":"Analgesia","enrollment":90},{"nctId":"NCT00799175","phase":"NA","title":"Local Infiltration Analgesia Following Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Region Örebro County","startDate":"2007-04","conditions":"Postoperative Pain","enrollment":48},{"nctId":"NCT00653926","phase":"NA","title":"Local Infiltration Analgesia Following Unicompartmental Knee Arthroplasty","status":"COMPLETED","sponsor":"Region Örebro County","startDate":"2005-09","conditions":"Postoperative Pain","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":120,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ropivicaine with Epinephrine","genericName":"Ropivicaine with Epinephrine","companyName":"Health Sciences North Research Institute","companyId":"health-sciences-north-research-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission, while epinephrine is a vasoconstrictor that prolongs the anesthetic's duration and reduces systemic absorption. Used for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}