Last reviewed · How we verify
lidocaine + epinephrine 1:100,000
lidocaine + epinephrine 1:100,000 is a Local anesthetic with vasoconstrictor Small molecule drug developed by Weill Medical College of Cornell University. It is currently FDA-approved for Local and regional anesthesia for surgical and dental procedures, Infiltration anesthesia for minor surgical procedures, Nerve blocks and epidural anesthesia. Also known as: Xylocaine + epinephrine 1:100,000.
Lidocaine blocks sodium channels to provide local anesthesia, while epinephrine causes vasoconstriction to prolong anesthetic duration and reduce systemic toxicity.
Lidocaine blocks sodium channels to provide local anesthesia, while epinephrine causes vasoconstriction to prolong anesthetic duration and reduce systemic toxicity. Used for Local and regional anesthesia for surgical and dental procedures, Infiltration anesthesia for minor surgical procedures, Nerve blocks and epidural anesthesia.
At a glance
| Generic name | lidocaine + epinephrine 1:100,000 |
|---|---|
| Also known as | Xylocaine + epinephrine 1:100,000 |
| Sponsor | Weill Medical College of Cornell University |
| Drug class | Local anesthetic with vasoconstrictor |
| Target | Voltage-gated sodium channels (lidocaine); alpha-1 and beta-1 adrenergic receptors (epinephrine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that reversibly inhibits sodium influx in nerve fibers, preventing depolarization and action potential propagation. Epinephrine (1:100,000 concentration) is a vasoconstrictor that reduces blood flow to the injection site, slowing lidocaine absorption into systemic circulation and extending the duration of local anesthesia while minimizing systemic toxicity.
Approved indications
- Local and regional anesthesia for surgical and dental procedures
- Infiltration anesthesia for minor surgical procedures
- Nerve blocks and epidural anesthesia
Common side effects
- Injection site reactions (pain, erythema)
- Transient paresthesia
- Headache
- Dizziness
- Tachycardia (from epinephrine)
- Hypertension (from epinephrine)
- Allergic reactions (rare)
Key clinical trials
- Comparison of Postoperative Effects of Articaine and Lidocaine in Mucogingival Surgery (NA)
- Bupivacaine Versus Lidocaine Infiltration for Postoperative Pain in Thyroid Surgery (PHASE2)
- Articaine Efficiency in Pulpectomy of Children With Irreversible Pulpitis Under the Age of Four (NA)
- Evaluation of Intraoperative Lagophthalmos Formula (NA)
- Study of the Success and Survival of Dental Composite Restorations Being Repaired Instead of Being Replaced (NA)
- A Novel Method for Chronic Anal Fissure Treatment (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- lidocaine + epinephrine 1:100,000 CI brief — competitive landscape report
- lidocaine + epinephrine 1:100,000 updates RSS · CI watch RSS
- Weill Medical College of Cornell University portfolio CI
Frequently asked questions about lidocaine + epinephrine 1:100,000
What is lidocaine + epinephrine 1:100,000?
How does lidocaine + epinephrine 1:100,000 work?
What is lidocaine + epinephrine 1:100,000 used for?
Who makes lidocaine + epinephrine 1:100,000?
Is lidocaine + epinephrine 1:100,000 also known as anything else?
What drug class is lidocaine + epinephrine 1:100,000 in?
What development phase is lidocaine + epinephrine 1:100,000 in?
What are the side effects of lidocaine + epinephrine 1:100,000?
What does lidocaine + epinephrine 1:100,000 target?
Related
- Drug class: All Local anesthetic with vasoconstrictor drugs
- Target: All drugs targeting Voltage-gated sodium channels (lidocaine); alpha-1 and beta-1 adrenergic receptors (epinephrine)
- Manufacturer: Weill Medical College of Cornell University — full pipeline
- Therapeutic area: All drugs in Anesthesia
- Indication: Drugs for Local and regional anesthesia for surgical and dental procedures
- Indication: Drugs for Infiltration anesthesia for minor surgical procedures
- Indication: Drugs for Nerve blocks and epidural anesthesia
- Also known as: Xylocaine + epinephrine 1:100,000
- Compare: lidocaine + epinephrine 1:100,000 vs similar drugs
- Pricing: lidocaine + epinephrine 1:100,000 cost, discount & access