{"id":"lidocaine-epinephrine-1-100-000","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions (pain, erythema)"},{"rate":null,"effect":"Transient paresthesia"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Tachycardia (from epinephrine)"},{"rate":null,"effect":"Hypertension (from epinephrine)"},{"rate":"<1","effect":"Allergic reactions (rare)"}]},"_chembl":{"chemblId":"CHEMBL1256958","moleculeType":"Small molecule","molecularWeight":"333.29"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lidocaine is a local anesthetic that reversibly inhibits sodium influx in nerve fibers, preventing depolarization and action potential propagation. Epinephrine (1:100,000 concentration) is a vasoconstrictor that reduces blood flow to the injection site, slowing lidocaine absorption into systemic circulation and extending the duration of local anesthesia while minimizing systemic toxicity.","oneSentence":"Lidocaine blocks sodium channels to provide local anesthesia, while epinephrine causes vasoconstriction to prolong anesthetic duration and reduce systemic toxicity.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:52:11.913Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia for surgical and dental procedures"},{"name":"Infiltration anesthesia for minor surgical procedures"},{"name":"Nerve blocks and epidural anesthesia"}]},"trialDetails":[{"nctId":"NCT07145879","phase":"NA","title":"Comparison of Postoperative Effects of Articaine and Lidocaine in Mucogingival Surgery","status":"COMPLETED","sponsor":"Pamukkale University","startDate":"2025-01-01","conditions":"Local Analgesia Via Infiltration, Wound Heal, Pain, Postoperative","enrollment":43},{"nctId":"NCT04427904","phase":"PHASE2","title":"Bupivacaine Versus Lidocaine Infiltration for Postoperative Pain in Thyroid Surgery","status":"UNKNOWN","sponsor":"St. Joseph's Healthcare Hamilton","startDate":"2022-06-01","conditions":"Postoperative Pain, Thyroid Diseases, Anesthesia, Local","enrollment":210},{"nctId":"NCT05944341","phase":"NA","title":"Articaine Efficiency in Pulpectomy of Children With Irreversible Pulpitis Under the Age of Four","status":"UNKNOWN","sponsor":"Minia University","startDate":"2023-06-01","conditions":"Dental Pulp Diseases","enrollment":164},{"nctId":"NCT04291625","phase":"NA","title":"Evaluation of Intraoperative Lagophthalmos Formula","status":"COMPLETED","sponsor":"Menoufia University","startDate":"2019-01-01","conditions":"Ptosis, Eyelid","enrollment":20},{"nctId":"NCT02046109","phase":"NA","title":"Study of the Success and Survival of Dental Composite Restorations Being Repaired Instead of Being Replaced","status":"WITHDRAWN","sponsor":"Dalhousie University","startDate":"2014-09","conditions":"Failing Dental Composite Restorations","enrollment":""},{"nctId":"NCT02628522","phase":"NA","title":"A Novel Method for Chronic Anal Fissure Treatment","status":"COMPLETED","sponsor":"Clinical Centre of Serbia","startDate":"2014-12","conditions":"Anal Fissure","enrollment":6}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Xylocaine + epinephrine 1:100,000"],"phase":"marketed","status":"active","brandName":"lidocaine + epinephrine 1:100,000","genericName":"lidocaine + epinephrine 1:100,000","companyName":"Weill Medical College of Cornell University","companyId":"weill-medical-college-of-cornell-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lidocaine blocks sodium channels to provide local anesthesia, while epinephrine causes vasoconstriction to prolong anesthetic duration and reduce systemic toxicity. Used for Local and regional anesthesia for surgical and dental procedures, Infiltration anesthesia for minor surgical procedures, Nerve blocks and epidural anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}