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Tumescent Solution with dilute epinephrine
Tumescent Solution with dilute epinephrine is a Local anesthetic with vasoconstrictor Small molecule drug developed by University of Wisconsin, Madison. It is currently FDA-approved for Local anesthesia and hemostasis in liposuction and body contouring procedures, Dermatologic and plastic surgical procedures requiring local anesthesia and reduced bleeding.
Tumescent solution with dilute epinephrine provides local anesthesia and hemostasis by infiltrating tissue with lidocaine and vasoconstricting blood vessels through epinephrine, reducing bleeding and allowing safer surgical procedures.
Tumescent solution with dilute epinephrine provides local anesthesia and hemostasis by infiltrating tissue with lidocaine and vasoconstricting blood vessels through epinephrine, reducing bleeding and allowing safer surgical procedures. Used for Local anesthesia and hemostasis in liposuction and body contouring procedures, Dermatologic and plastic surgical procedures requiring local anesthesia and reduced bleeding.
At a glance
| Generic name | Tumescent Solution with dilute epinephrine |
|---|---|
| Sponsor | University of Wisconsin, Madison |
| Drug class | Local anesthetic with vasoconstrictor |
| Modality | Small molecule |
| Therapeutic area | Surgery/Anesthesia |
| Phase | FDA-approved |
Mechanism of action
The solution combines a local anesthetic (lidocaine) with a dilute vasoconstrictor (epinephrine) to create a tumescent (swollen, firm) tissue plane. The epinephrine causes vasoconstriction, which minimizes blood loss and improves surgical visibility, while the lidocaine provides local pain relief. This technique is widely used in liposuction, dermatologic surgery, and other procedures requiring hemostasis and anesthesia.
Approved indications
- Local anesthesia and hemostasis in liposuction and body contouring procedures
- Dermatologic and plastic surgical procedures requiring local anesthesia and reduced bleeding
Common side effects
- Tumescence/swelling at injection site
- Bruising
- Temporary numbness
- Tachycardia (from epinephrine)
- Lidocaine toxicity (rare, with overdose)
Key clinical trials
- Prospective Evaluation of Efficacy of Tumescent Steroid Infiltration in Mandibular Third Molar Surgery: a Split Mouth Randomized Study (NA)
- EFFECTS OF TRANEXAMIC ACID IN TUMESCENT SOLUTION FOR LIPOSUCTION PROCEDURES (PHASE4)
- A Comparison of Tumescence in Breast Reduction Surgery (PHASE4)
- Tumescent Lidocaine Maximum Safe mg/kg Dosage (PHASE1, PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Tumescent Solution with dilute epinephrine CI brief — competitive landscape report
- Tumescent Solution with dilute epinephrine updates RSS · CI watch RSS
- University of Wisconsin, Madison portfolio CI
Frequently asked questions about Tumescent Solution with dilute epinephrine
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Related
- Drug class: All Local anesthetic with vasoconstrictor drugs
- Manufacturer: University of Wisconsin, Madison — full pipeline
- Therapeutic area: All drugs in Surgery/Anesthesia
- Indication: Drugs for Local anesthesia and hemostasis in liposuction and body contouring procedures
- Indication: Drugs for Dermatologic and plastic surgical procedures requiring local anesthesia and reduced bleeding
- Compare: Tumescent Solution with dilute epinephrine vs similar drugs
- Pricing: Tumescent Solution with dilute epinephrine cost, discount & access