{"id":"tumescent-solution-with-dilute-epinephrine","safety":{"commonSideEffects":[{"rate":null,"effect":"Tumescence/swelling at injection site"},{"rate":null,"effect":"Bruising"},{"rate":null,"effect":"Temporary numbness"},{"rate":null,"effect":"Tachycardia (from epinephrine)"},{"rate":null,"effect":"Lidocaine toxicity (rare, with overdose)"}]},"_chembl":{"chemblId":"CHEMBL1256958","moleculeType":"Small molecule","molecularWeight":"333.29"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The solution combines a local anesthetic (lidocaine) with a dilute vasoconstrictor (epinephrine) to create a tumescent (swollen, firm) tissue plane. The epinephrine causes vasoconstriction, which minimizes blood loss and improves surgical visibility, while the lidocaine provides local pain relief. This technique is widely used in liposuction, dermatologic surgery, and other procedures requiring hemostasis and anesthesia.","oneSentence":"Tumescent solution with dilute epinephrine provides local anesthesia and hemostasis by infiltrating tissue with lidocaine and vasoconstricting blood vessels through epinephrine, reducing bleeding and allowing safer surgical procedures.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:39:14.440Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia and hemostasis in liposuction and body contouring procedures"},{"name":"Dermatologic and plastic surgical procedures requiring local anesthesia and reduced bleeding"}]},"trialDetails":[{"nctId":"NCT07436546","phase":"NA","title":"Prospective Evaluation of Efficacy of Tumescent Steroid Infiltration in Mandibular Third Molar Surgery: a Split Mouth Randomized Study","status":"COMPLETED","sponsor":"Postgraduate Institute of Dental Sciences Rohtak","startDate":"2025-03-23","conditions":"Impacted Third Molar, Impacted Third Molar Tooth, Third Molar Extraction","enrollment":25},{"nctId":"NCT06648265","phase":"PHASE4","title":"EFFECTS OF TRANEXAMIC ACID IN TUMESCENT SOLUTION FOR LIPOSUCTION PROCEDURES","status":"COMPLETED","sponsor":"Total Definer Research Group","startDate":"2022-01-20","conditions":"Liposuction, Bruising, Inflammation","enrollment":78},{"nctId":"NCT01602692","phase":"PHASE4","title":"A Comparison of Tumescence in Breast Reduction Surgery","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2012-08","conditions":"Pain, Postoperative, Postoperative Nausea and Vomiting","enrollment":40},{"nctId":"NCT00977028","phase":"PHASE1, PHASE2","title":"Tumescent Lidocaine Maximum Safe mg/kg Dosage","status":"UNKNOWN","sponsor":"Klein, Jeffrey A., M.D.","startDate":"2005-01","conditions":"Anesthesia","enrollment":14}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Tumescent Solution with dilute epinephrine","genericName":"Tumescent Solution with dilute epinephrine","companyName":"University of Wisconsin, Madison","companyId":"university-of-wisconsin-madison","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tumescent solution with dilute epinephrine provides local anesthesia and hemostasis by infiltrating tissue with lidocaine and vasoconstricting blood vessels through epinephrine, reducing bleeding and allowing safer surgical procedures. Used for Local anesthesia and hemostasis in liposuction and body contouring procedures, Dermatologic and plastic surgical procedures requiring local anesthesia and reduced bleeding.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}