Last reviewed · How we verify
L:Lidocaine
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia for minor surgical procedures, Topical anesthesia for skin and mucous membranes, Infiltration anesthesia.
At a glance
| Generic name | L:Lidocaine |
|---|---|
| Also known as | Xylocard |
| Sponsor | B.P. Koirala Institute of Health Sciences |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting voltage-gated sodium channels in the axonal membrane of nerves. This prevents depolarization and the generation of action potentials, thereby blocking pain signal transmission. It is used topically or by injection to produce local anesthesia in specific tissues or regions.
Approved indications
- Local anesthesia for minor surgical procedures
- Topical anesthesia for skin and mucous membranes
- Infiltration anesthesia
- Nerve blocks
Common side effects
- Localized reactions (erythema, edema)
- Systemic toxicity (tremors, seizures, cardiac arrhythmias)
- Allergic reactions
- Methemoglobinemia (with topical use)
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |