{"id":"l-lidocaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Localized reactions (erythema, edema)"},{"rate":null,"effect":"Systemic toxicity (tremors, seizures, cardiac arrhythmias)"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Methemoglobinemia (with topical use)"}]},"_chembl":null,"_dailymed":{"setId":"846a49a1-c31e-73b9-e053-2a91aa0a0f95","title":"PM EXTERNAL (ECONAZOLE NITRATE, SALICYLIC ACID, LIDOCAINE, L-MENTHOL) SOLUTION [OASIS TRADING]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lidocaine is a local anesthetic that works by inhibiting voltage-gated sodium channels in the axonal membrane of nerves. This prevents depolarization and the generation of action potentials, thereby blocking pain signal transmission. It is used topically or by injection to produce local anesthesia in specific tissues or regions.","oneSentence":"Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:51:21.752Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia for minor surgical procedures"},{"name":"Topical anesthesia for skin and mucous membranes"},{"name":"Infiltration anesthesia"},{"name":"Nerve blocks"}]},"trialDetails":[{"nctId":"NCT01990781","phase":"PHASE4","title":"Effect of Intravenous Lidocaine and Dexamethasone Combination on Postoperative Sore Throat, Cough and Hoarseness.","status":"COMPLETED","sponsor":"B.P. Koirala Institute of Health Sciences","startDate":"2013-12","conditions":"Postoperative Sore Throat, Cough, Hoarseness","enrollment":180}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":80,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Xylocard"],"phase":"marketed","status":"active","brandName":"L:Lidocaine","genericName":"L:Lidocaine","companyName":"B.P. Koirala Institute of Health Sciences","companyId":"b-p-koirala-institute-of-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia for minor surgical procedures, Topical anesthesia for skin and mucous membranes, Infiltration anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}