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Levobupivacaine PCA group
Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Postoperative pain management via patient-controlled analgesia (PCA), Regional anesthesia and analgesia.
At a glance
| Generic name | Levobupivacaine PCA group |
|---|---|
| Also known as | Postoperative continuous wound infiltration analgesia with local anesthetic, Chirocaine 0.5% |
| Sponsor | Osijek University Hospital |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Pain Management |
| Phase | FDA-approved |
Mechanism of action
Levobupivacaine is the S-enantiomer of bupivacaine, a long-acting amide local anesthetic. It works by reversibly binding to and blocking voltage-gated sodium channels on the inner surface of nerve cell membranes, thereby preventing depolarization and conduction of nerve impulses. When administered via patient-controlled analgesia (PCA), it provides regional anesthesia and postoperative pain relief.
Approved indications
- Postoperative pain management via patient-controlled analgesia (PCA)
- Regional anesthesia and analgesia
Common side effects
- Hypotension
- Bradycardia
- Nausea
- Dizziness
- Systemic toxicity (at high doses)
Key clinical trials
- Efficacy of Scalp Block in Managing Post Subarachnoid Hemorrhage Headache in Critically Ill Patients. A Single Centre Randomized Controlled Trial (NA)
- Investigation of Antibacterial Effect of Levobupivacaine on Staphylococcus Aureus (NA)
- Long-term Outcomes of Breast Cancer Patients After Wound Infiltration Analgesia (PHASE4)
- Lumbar Erector Spinae Plane Block for Back Surgery (PHASE3)
- Postoperative Analgesia With a Catheter Under the Erector Spinae Muscle for Videothoracoscopic Lung Surgery (NA)
- Multimodal Analgesia in Major Abdominal Pediatric Cancer Surgeries (NA)
- Parasternal Block and TENS for Cardiac Surgery (NA)
- Transversus Abdominis Plane Block for Laparoscopic Hysterectomy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Levobupivacaine PCA group CI brief — competitive landscape report
- Levobupivacaine PCA group updates RSS · CI watch RSS
- Osijek University Hospital portfolio CI