{"id":"levobupivacaine-pca-group","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Systemic toxicity (at high doses)"}]},"_chembl":{"chemblId":"CHEMBL1201193","moleculeType":"Small molecule","molecularWeight":"288.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levobupivacaine is the S-enantiomer of bupivacaine, a long-acting amide local anesthetic. It works by reversibly binding to and blocking voltage-gated sodium channels on the inner surface of nerve cell membranes, thereby preventing depolarization and conduction of nerve impulses. When administered via patient-controlled analgesia (PCA), it provides regional anesthesia and postoperative pain relief.","oneSentence":"Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:51:54.091Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain management via patient-controlled analgesia (PCA)"},{"name":"Regional anesthesia and analgesia"}]},"trialDetails":[{"nctId":"NCT07307508","phase":"NA","title":"Efficacy of Scalp Block in Managing Post Subarachnoid Hemorrhage Headache in Critically Ill Patients. A Single Centre Randomized Controlled Trial","status":"RECRUITING","sponsor":"Hamad Medical Corporation","startDate":"2025-10-22","conditions":"Aneurysmal Subarachnoid Hemorrhage (aSAH), Headache Disorders","enrollment":22},{"nctId":"NCT07285759","phase":"NA","title":"Investigation of Antibacterial Effect of Levobupivacaine on Staphylococcus Aureus","status":"COMPLETED","sponsor":"Dokuz Eylul University","startDate":"2010-11","conditions":"Staphylococcus Aureus Bacterial Contamination","enrollment":40},{"nctId":"NCT05829707","phase":"PHASE4","title":"Long-term Outcomes of Breast Cancer Patients After Wound Infiltration Analgesia","status":"COMPLETED","sponsor":"Osijek University Hospital","startDate":"2009-01-05","conditions":"Postoperative Analgesia, Hand Strength, Health Related Quality of Life","enrollment":120},{"nctId":"NCT03825198","phase":"PHASE3","title":"Lumbar Erector Spinae Plane Block for Back Surgery","status":"UNKNOWN","sponsor":"Dr M. B. Breebaart","startDate":"2019-08-01","conditions":"Pain, Postoperative, Anaesthesia, Surgery","enrollment":80},{"nctId":"NCT04665531","phase":"NA","title":"Postoperative Analgesia With a Catheter Under the Erector Spinae Muscle for Videothoracoscopic Lung Surgery","status":"COMPLETED","sponsor":"Surgery Bitenc","startDate":"2020-02-19","conditions":"Neoplasm of Lung, Thoracic Surgery, Video-Assisted","enrollment":50},{"nctId":"NCT03580980","phase":"NA","title":"Multimodal Analgesia in Major Abdominal Pediatric Cancer Surgeries","status":"COMPLETED","sponsor":"National Cancer Institute, Egypt","startDate":"2015-04-01","conditions":"Pediatric Cancer, Pain, Postoperative","enrollment":90},{"nctId":"NCT02725229","phase":"NA","title":"Parasternal Block and TENS for Cardiac Surgery","status":"COMPLETED","sponsor":"Antalya Training and Research Hospital","startDate":"2011-06","conditions":"Postoperative Pain","enrollment":120},{"nctId":"NCT01552148","phase":"PHASE4","title":"Transversus Abdominis Plane Block for Laparoscopic Hysterectomy","status":"COMPLETED","sponsor":"Istituti Ospitalieri di Cremona","startDate":"2012-03","conditions":"Hysterectomy, Laparoscopic Surgery","enrollment":52}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Postoperative continuous wound infiltration analgesia with local anesthetic, Chirocaine 0.5%"],"phase":"marketed","status":"active","brandName":"Levobupivacaine PCA group","genericName":"Levobupivacaine PCA group","companyName":"Osijek University Hospital","companyId":"osijek-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Postoperative pain management via patient-controlled analgesia (PCA), Regional anesthesia and analgesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}