Last reviewed · How we verify
Dyclonine hydrochloride mucilage
Dyclonine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission.
Dyclonine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission. Used for Topical anesthesia of oral and pharyngeal mucosa, Relief of pain and discomfort in the mouth and throat.
At a glance
| Generic name | Dyclonine hydrochloride mucilage |
|---|---|
| Sponsor | Peking Union Medical College Hospital |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Pain management / Otolaryngology |
| Phase | FDA-approved |
Mechanism of action
Dyclonine is a topical local anesthetic that works by stabilizing the neuronal membrane and inhibiting the initiation and conduction of nerve impulses. When formulated as a mucilage, it provides prolonged contact with mucosal surfaces, allowing sustained local anesthetic effect for pain relief in the oral cavity and throat. The mucilage formulation enhances adhesion and duration of action compared to standard solutions.
Approved indications
- Topical anesthesia of oral and pharyngeal mucosa
- Relief of pain and discomfort in the mouth and throat
Common side effects
- Local irritation or burning sensation
- Allergic contact dermatitis
- Methemoglobinemia (rare, with excessive use)
Key clinical trials
- Oral Ondansetron to Improve Patient Experience of Unsedated Esophagogastroduodenoscopy Pilot Study (PHASE4)
- Ondansetron Combined with Dyclonine Hydrochloride to Improve Patient Experience in Unsedated Esophagogastro-duodenoscopy (PHASE4)
- Premedication Dyclonine Improves Visibility During Bowel Cleansing for Colonoscopy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: