{"id":"dyclonine-hydrochloride-mucilage","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning sensation"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Methemoglobinemia (rare, with excessive use)"}]},"_chembl":{"chemblId":"CHEMBL1200478","moleculeType":"Small molecule","molecularWeight":"325.88"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dyclonine is a topical local anesthetic that works by stabilizing the neuronal membrane and inhibiting the initiation and conduction of nerve impulses. When formulated as a mucilage, it provides prolonged contact with mucosal surfaces, allowing sustained local anesthetic effect for pain relief in the oral cavity and throat. The mucilage formulation enhances adhesion and duration of action compared to standard solutions.","oneSentence":"Dyclonine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:35:46.341Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical anesthesia of oral and pharyngeal mucosa"},{"name":"Relief of pain and discomfort in the mouth and throat"}]},"trialDetails":[{"nctId":"NCT07264738","phase":"PHASE4","title":"Oral Ondansetron to Improve Patient Experience of Unsedated Esophagogastroduodenoscopy Pilot Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Peking Union Medical College Hospital","startDate":"2025-07-01","conditions":"Esophagogastroduodensocopy (EGD) Procedure","enrollment":40},{"nctId":"NCT06729307","phase":"PHASE4","title":"Ondansetron Combined with Dyclonine Hydrochloride to Improve Patient Experience in Unsedated Esophagogastro-duodenoscopy","status":"NOT_YET_RECRUITING","sponsor":"Peking Union Medical College Hospital","startDate":"2025-01","conditions":"Esophagogastroduodensocopy (EGD) Procedure","enrollment":260},{"nctId":"NCT03352700","phase":"PHASE4","title":"Premedication Dyclonine Improves Visibility During Bowel Cleansing for Colonoscopy","status":"UNKNOWN","sponsor":"Changhai Hospital","startDate":"2017-12-01","conditions":"Bowel Preparation Scale, the Amount of Air Bubble, Adenoma Detection Rate","enrollment":580}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Dyclonine hydrochloride mucilage","genericName":"Dyclonine hydrochloride mucilage","companyName":"Peking Union Medical College Hospital","companyId":"peking-union-medical-college-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dyclonine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission. Used for Topical anesthesia of oral and pharyngeal mucosa, Relief of pain and discomfort in the mouth and throat.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}