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Same Bupivacaine Concentration
Same Bupivacaine Concentration is a Local anesthetic Small molecule drug developed by University of Chile. It is currently FDA-approved for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks.
At a glance
| Generic name | Same Bupivacaine Concentration |
|---|---|
| Sponsor | University of Chile |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and action potential propagation. This results in local anesthesia and loss of sensation in the infiltrated tissue. The drug is long-acting due to its high lipophilicity and protein binding, allowing sustained neural blockade.
Approved indications
- Local and regional anesthesia for surgical procedures
- Infiltration anesthesia
- Nerve blocks
- Epidural and spinal anesthesia
Common side effects
- Systemic toxicity (CNS effects: tremor, seizures)
- Cardiovascular effects (hypotension, arrhythmias)
- Allergic reactions
- Methemoglobinemia
Key clinical trials
- Comparison of the Analgesic Efficacy of Chest Wall Blocks in Coronary Artery Bypass Surgery (NA)
- Epidural vs. Dural Puncture Epidural in Labor Analgesia (NA)
- Analgesic Efficacy of Bilateral Erector Spinae Plane Block in Pediatric Tethered Cord Syndrome Surgery (NA)
- US-guided Pericapsular Nerve Group (PENG) Block in Different Volumes on Postoperative Pain in Hip Replacement Surgeries (NA)
- EXORA vs ESP Blocks in Laparoscopic Cholecystectomy (NA)
- Effectiveness of Retrolaminar Block in Lumbar Spine Fusion With Multimodal Analgesia (NA)
- Blood Bupivacaine Concentration After Regional Block Applications in Pediatric Patients (NA)
- Para-sartorial Compartment Block in Knee Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Same Bupivacaine Concentration CI brief — competitive landscape report
- Same Bupivacaine Concentration updates RSS · CI watch RSS
- University of Chile portfolio CI
Frequently asked questions about Same Bupivacaine Concentration
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Related
- Drug class: All Local anesthetic drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: University of Chile — full pipeline
- Therapeutic area: All drugs in Anesthesia
- Indication: Drugs for Local and regional anesthesia for surgical procedures
- Indication: Drugs for Infiltration anesthesia
- Indication: Drugs for Nerve blocks
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing