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NCT07291388: RBLUF
Effectiveness of Retrolaminar Block in Reducing Postoperative Opioid Consumption in Patients Undergoing Lumbar Spine Fusion With Multimodal Analgesia
NA trial testing retrolaminar block in Acute Pain in 44 participants. Not yet recruiting.
1 December 2026
Quick facts
| Lead sponsor | Pontificia Universidad Catolica de Chile |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 44 |
| Start date | 1 December 2025 |
| Primary completion | 1 December 2026 |
| Estimated completion | 1 March 2027 |
Drugs / interventions tested
- retrolaminar block
- Sham block — full drug profile →
Conditions studied
- Acute Pain — all drugs for Acute Pain →
- Anesthesia — all drugs for Anesthesia →
- Lumbar Spine Disease — all drugs for Lumbar Spine Disease →
Sponsor
Pontificia Universidad Catolica de Chile — full company profile →
Who can join
Adults 18 to 75, any sex, with Acute Pain or Anesthesia. Healthy volunteers can join.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Opioid consumption during the first 24 hours postoperative
Time frame: Daily consumption during the first 24 hours
To assess rescue opioid consumption, expressed as morphine equivalents, during the first 24 hours postoperative.
Sponsor's own description
This randomized, blinded, controlled clinical trial aims to evaluate the effectiveness of ultrasound-guided retrolaminar block in reducing postoperative opioid consumption in patients undergoing lumbar spine fusion surgery under multimodal analgesia. The participants will: * Be randomly assigned in a 1:1 ratio to receive either a retrolaminar block with 0.25% bupivacaine plus epinephrine or a sham block (normal saline) prior to surgical incision. * Receive standardized multimodal analgesia. * Have follow-up by the Acute Pain Unit during the first 3 days, to assess opioid consumption (morphine) in 24 hours, pain intensity measured by Numeric Rating Scale, quality of recovery assessed by the QoR-15 questionnaire, intraoperative blood loss, and postoperative complications.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07291388
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of retrolaminar block
Trials testing the same drug.
- NCT06230575 — Locoregional Blocks for Breast Cancer Surgeries · NA · completed
- NCT04336111 — Ultrasound Guided Bilateral Retrolaminar Block as Analgesia for Adolescent Idiopathic Scoliosis Correction · NA · recruiting
- NCT05755815 — Retrolaminar Block Versus Intraperitoneal Block for Laparoscopic Cholecystectomy · NA · completed
- NCT05705739 — Ultrasound Guided Erector Spinae Plane Block Versus Retrolaminar Plane Block · NA · completed
- NCT04343937 — Retrolaminar Block for Postoperative Analgesia in Lumbar Herniectomy Surgery · completed
Other recruiting trials for Acute Pain
Currently open trials in the same condition.
- NCT06779604 — Dexmedetomidine and Dexamethasone Added as Adjuvant Infraclavicular Brachial Plexus Block in Upper Limb Surgery · recruiting
- NCT07348419 — Quadro-Iliac vs Thoracolumbar Interfascial Plane Block for Analgesia After Single-Level Lumbar Disc Surgery · NA · recruiting
- NCT07335159 — Does Patient Testimonial Improve the Pain Relief Derived From a Brief Intervention · NA · recruiting
- NCT07348523 — Comparison of the Postoperative Analgesic Efficacy of Classical and Modified Erector Spinae Plane Blocks After Lumbar Sp · NA · recruiting
- NCT07336264 — Characterization of Acute Pain · recruiting
Other Pontificia Universidad Catolica de Chile trials
Trials by the same sponsor.
- NCT07396129 — Assessing the Efficacy of a High-Dose Lidocaine-Tetracaine Cream for the Treatment of Peripheral Neuropathic Pain · Phase 1, PHASE2 · not yet recruiting
- NCT07510425 — Artificial Intelligence vs. Automated Messaging for Continuous Regional Analgesia Follow-up · NA · not yet recruiting
- NCT07380451 — Modular Intervention for Depression Study · NA · not yet recruiting
- NCT07324499 — Effect of Dexamethasone on Plasma Levels of Bupivacaine and Dexamethasone After a Single-injection Interscalene Nerve Bl · NA · not yet recruiting
- NCT07330947 — Incidence and Risk Factors of Postoperative Chronic Pain in Patients Who Have Undergone Hallux Valgus Surgery · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07291388 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Pontificia Universidad Catolica de Chile
- Last refreshed: 5 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07291388.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing