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Intravenous Lidocaine
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia and infiltration anesthesia, Ventricular arrhythmias (acute management), Chronic pain conditions (off-label use in some settings).
At a glance
| Generic name | Intravenous Lidocaine |
|---|---|
| Also known as | 2%Intravenous Lidocaine, IV lidocaine, lignocaine, Xylocaine, Chlorydrate de Lidocaine 2% |
| Sponsor | Khon Kaen University |
| Drug class | Local anesthetic; antiarrhythmic agent |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia; Cardiology; Pain management |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in the neuronal cell membrane. This prevents depolarization and the generation of action potentials, thereby blocking pain signal transmission. When administered intravenously, it can also have systemic effects including antiarrhythmic properties and anti-inflammatory effects.
Approved indications
- Local anesthesia and infiltration anesthesia
- Ventricular arrhythmias (acute management)
- Chronic pain conditions (off-label use in some settings)
Common side effects
- Dizziness or lightheadedness
- Tremor or twitching
- Nausea
- Hypotension
- Cardiac arrhythmias (at high doses)
- Seizures (at toxic doses)
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Sphenopalatine Ganglion Block for Post-Dural Puncture Headache: A Pilot Randomised Controlled Trial (NA)
- Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial (PHASE3)
- Intravenous Lidocaine Infusion in Lumbar Fusion Surgery (NA)
- Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplasty (PHASE4)
- Effect of IV Lidocaine on Duodenal Peristalsis and Sedation in ERCP (PHASE4)
- Effect of Perioperative Lidocaine or High-Dose Dexamethasone on Immune Response in Colon Cancer Surgery (PILDI Study) (PHASE2)
- Application of Low-dose Muscle Relaxants in Bronchoscopic Interventional Procedures (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Intravenous Lidocaine CI brief — competitive landscape report
- Intravenous Lidocaine updates RSS · CI watch RSS
- Khon Kaen University portfolio CI