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Isobaric 2-chloroprocaine
Isobaric 2-chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission.
Isobaric 2-chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission. Used for Local and regional anesthesia for surgical procedures, Intrathecal anesthesia for spinal procedures.
At a glance
| Generic name | Isobaric 2-chloroprocaine |
|---|---|
| Also known as | Ampres, Ampres 10mg/ml |
| Sponsor | Centre Hospitalier Universitaire Saint Pierre |
| Drug class | Local anesthetic (ester) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
As a local anesthetic agent, 2-chloroprocaine works by inhibiting sodium influx through voltage-gated sodium channels in nerve fibers, thereby preventing depolarization and conduction of action potentials. The isobaric formulation is designed to have a specific gravity matching cerebrospinal fluid, allowing for controlled distribution when administered intrathecally. This enables localized anesthesia with predictable spread and duration.
Approved indications
- Local and regional anesthesia for surgical procedures
- Intrathecal anesthesia for spinal procedures
Common side effects
- Transient neurological symptoms (TNS)
- Hypotension
- Bradycardia
- Headache
- Back pain
- Allergic reactions
Key clinical trials
- Optimizing Anesthesia for Post Partum Tubal Ligations (PHASE2)
- Comparison of Hyperbaric Prilocaine With Chloroprocaine for Intrathecal Anaesthesia in Day Case Knee Arthroscopy (PHASE4)
- Estimation of Effective Dose 95 (ED95) of Intrathecal Isobaric 2-chloroprocaine (2-CP) Based on the Height (cm) of a Patient Undergoing Ambulatory Knee Arthroscopy
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Isobaric 2-chloroprocaine CI brief — competitive landscape report
- Isobaric 2-chloroprocaine updates RSS · CI watch RSS
- Centre Hospitalier Universitaire Saint Pierre portfolio CI